THR BETA RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREOF

1 - 30 . (canceled)

31 . A method of preparing a compound of Formula (I):

or a salt thereof, wherein:

Ring A is a C 5-10 aliphatic ring or a C 5-10 aromatic ring, each optionally substituted with one or more substituents independently selected from the group consisting of hydrogen, halogen atoms, hydroxy, —OCF 3 , —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl) 2 , —CONH 2 , —CONHC 1-4 alkyl, —CON(C 1-4 alkyl) 2 , —NHCOC 1-4 alkyl, C 1-6 alkyl, C 1-6 alkoxy, and C 3-6 cycloalkyl, and when two substituents are contained, the two substituents can form a ring structure together with the carbon connected thereto; and the halogen atoms are selected from the group consisting of F, Cl, and Br;

R 1 is selected from the group consisting of hydrogen, cyano, substituted or unsubstituted C 1-6 alkyl, and substituted or unsubstituted C 3-6 cycloalkyl, the substituent being selected from the group consisting of halogen atoms, hydroxy, and C 1-6 alkoxy; and

R 2 and R 3 are each independently selected from the group consisting of halogen atoms and substituted or unsubstituted C 1-6 alkyl, the substituent being selected from the group consisting of halogen atoms, hydroxy, and C 1-6 alkoxy;

the method comprising subjecting a compound of Formula (I-e):

or a salt thereof, to an alkaline or acidic environment to form a compound of Formula (I-f):

or a salt thereof; and

contacting a compound of Formula (I-g):

or a salt thereof, with the compound of Formula (1-f), or a salt thereof, to form the compound of Formula (I), or a salt thereof.

32 . The method of claim 31 , wherein the compound of Formula (I-f), is selected from the group consisting of:

or a salt thereof,

the compound of Formula (I-g) is:

or a salt thereof, and

the compound of Formula (I), is selected from the group consisting of:

or a salt thereof.

33 . The method of claim 32 , wherein the compound of Formula (I-f), is selected from the group consisting of:

or a salt thereof, and

the compound of Formula (I), is selected from the group consisting of:

or a salt thereof.

34 . The method of claim 31 , wherein the compound of Formula (I-f) is:

or a salt thereof,

the compound of Formula (I-g) is:

or a salt thereof, and

the compound of Formula (I) is:

or a salt thereof.

35 . The method of claim 31 , wherein the contacting occurs in an acidic aqueous solution comprising a nitrite.

36 . The method of claim 32 , wherein the contacting occurs in an acidic aqueous solution comprising a nitrite.

37 . The method of claim 33 , wherein the contacting occurs in an acidic aqueous solution comprising a nitrite.

38 . The method of claim 34 , wherein the contacting occurs in an acidic aqueous solution comprising a nitrite.

39 . The method of claim 31 , further comprising subjecting a compound of Formula (I-c):

or a salt thereof, to a coupling reaction with a compound of Formula (I-d):

or a salt thereof, to form the compound of Formula (I-e), or a salt thereof.

40 . The method of claim 32 , further comprising subjecting a compound selected from the group consisting of:

or a salt thereof, to a coupling reaction with a compound:

or a salt thereof, to form the compound of Formula (I-e), or a salt thereof, wherein the compound of Formula (I-e) is selected from the group consisting of:

41 . The method of claim 33 , further comprising subjecting a compound selected from the group consisting of:

or a salt thereof, to a coupling reaction with a compound:

or a salt thereof, to form the compound of Formula (I-e), or a salt thereof, wherein the compound of Formula (I-e) is selected from the group consisting of:

42 . The method of claim 34 , further comprising subjecting a compound:

or a salt thereof, to a coupling reaction with a compound:

or a salt thereof, to produce the compound:

or a salt thereof.

43 . A method of preparing a compound of Formula (I):

or a salt thereof, wherein:

Ring A is a C 5-10 aliphatic ring or a C 5-10 aromatic ring, each optionally substituted with one or more substituents independently selected from the group consisting of hydrogen, halogen atoms, hydroxy, —OCF 3 , —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl) 2 , —CONH 2 , —CONHC 1-4 alkyl, —CON(C 1-4 alkyl) 2 , —NHCOC 1-4 alkyl, C 1-6 alkyl, C 1-6 alkoxy, and C 3-6 cycloalkyl, and when two substituents are contained, the two substituents can form a ring structure together with the carbon connected thereto; and the halogen atoms are selected from the group consisting of F, Cl, and Br;

R 1 is selected from the group consisting of hydrogen, cyano, substituted or unsubstituted C 1-6 alkyl, and substituted or unsubstituted C 3-6 cycloalkyl, the substituent being selected from the group consisting of halogen atoms, hydroxy, and C 1-6 alkoxy; and

R 2 and R 3 are each independently selected from the group consisting of halogen atoms and substituted or unsubstituted C 1-6 alkyl, the substituent being selected from the group consisting of halogen atoms, hydroxy, and C 1-6 alkoxy;

the method comprising subjecting a compound of Formula (I-e):

or a salt thereof, to an alkaline or acidic environment to produce a compound of Formula (I-f):

or a salt thereof,

substituting the amine of the compound of Formula (I-f), or a salt thereof, with a halide to form a halide-substituted compound, or a salt thereof; and

coupling a compound of Formula (I-h):

or a salt thereof, to the halide-substituted compound, or a salt thereof, to form the compound of Formula (I), or a salt thereof.

44 . The method of claim 43 , further comprising subjecting a compound of Formula (I-c):

or a salt thereof, to a coupling reaction with a compound of Formula (I-d):

or a salt thereof, to produce the compound of Formula (I-e), or a salt thereof.

45 . The method of claim 43 , wherein the compound of Formula (I-f), is selected from the group consisting of:

or a salt thereof,

the compound of Formula (I-h) is:

or a salt thereof, and

the compound of Formula (I) is selected from the group consisting of:

or a salt thereof.

46 . The method of claim 43 , wherein the compound of Formula (I-f), is selected from the group consisting of:

or a salt thereof, and

the compound of Formula (I) is selected from the group consisting of:

or a salt thereof.

47 . The method of claim 43 , wherein the compound of Formula (I-f) is:

or a salt thereof; and

the compound of Formula (I) is:

or a salt thereof.

48 . The method of claim 43 , wherein the substituting comprises a diazonium-mediated substitution.

49 . The method of claim 46 , wherein the substituting comprises a diazonium-mediated substitution.

50 . The method of claim 47 , wherein the substituting comprises a diazonium-mediated substitution.