IP Library › Granted Patent US 12,497,618
Granted Patent B1
US 12,497,618 · App. 19/323,583 · Granted Dec 16, 2025

Composition for regulating production of interfering ribonucleic acid

Inventor: Bradley G. Thompson (Calgary, CA)
Assignee: Wyvern Pharmaceuticals Inc.
C12N15/113C12N15/85C12N2310/141
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Quick Facts
Patent No.
US 12,497,618
App. No.
19/323,583
Granted
Dec 16, 2025
Kind
B1
Abstract

The embodiments of the present disclosure relate to one or more compositions or methods that upregulate the production of one or more sequences of micro-interfering ribonucleic acid (miRNA). The sequences of miRNA may be complimentary to a sequence of target messenger RNA (mRNA) that encodes for the translation of a target biomolecule, such as epidermal growth factor receptor kinase substrate 8 (EPS8). The miRNA can cause the target mRNA to be degraded or inactivated, thereby causing a decrease in bioavailability of the target biomolecule because it is degraded or inactivated by the miRNA. Decreasing the bioavailability of the target biomolecule within a subject that is administered the one or more compositions may address the afflictions experienced by the subject due to expression of the target biomolecule.

Claims (4)

1 . A composition that comprises a recombinant plasmid (RP) comprising a sequence of nucleotides that is 100% identical to SEQ ID NO. 2, wherein the sequence of nucleotides encodes a sequence of micro-interfering ribonucleic acid (miRNA) that binds to and causes inactivation and/or degradation of messenger ribonucleic acid (mRNA) that encodes for a target molecule.

2 . The composition of claim 1 , wherein the sequence of nucleotides is encapsulated in a protein coat, a lipid vesicle, or any combination thereof.

3 . The composition of claim 1 , wherein the target molecule is epidermal growth factor receptor kinase substrate 8 (EPS8).

4 . A composition that comprises a recombinant plasmid (RP) with a sequence of nucleotides that encodes a sequence of micro-interfering ribonucleic acid (miRNA) that binds to and causes inactivation and/or degradation of messenger ribonucleic acid (mRNA) that encodes for epidermal growth factor receptor kinase substrate 8 (EPS8), wherein the sequence of nucleotides is 95% to 100% identical to SEQ ID NO. 3 and comprises an insert sequence that is 100% identical to SEQ ID No. 2.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2025
From: THOMPSON, BRADLEY G.
To: WYVERN PHARMACEUTICALS INC.
Reel/Frame 072203/0452 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2025
From: THOMPSON, BRADLEY G.
To: WYVERN PHARMACEUTICALS INC.
Reel/Frame 072203/0668 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2025
From: THOMPSON, BRADLEY G.
To: WYVERN PHARMACEUTICALS INC.
Reel/Frame 072203/0739 →
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