IP Library › Patent Application 19350487
Patent Application
App. No. 19/350,487

ISOINDOLINE COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE

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Quick Facts
Patent No.
US None
App. No.
19/350,487
Abstract

Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.

Claims (8)

1 .- 37 . (canceled)

38 . A pharmaceutical composition comprising about 0.01 mg/kg/day to about 25 mg/kg/day, of a compound of the Formula:

or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.

39 . The pharmaceutical composition of claim 38 wherein the compound is

40 . The pharmaceutical composition of claim 38 wherein the composition comprises about 0.1 mg/kg/day to about 10 mg/kg/day of the compound.

41 . The pharmaceutical composition of claim 38 wherein the composition comprises about 0.2 mg/kg/day to about 5 mg/kg/day mg of the compound.

42 . The pharmaceutical composition of claim 38 wherein the composition is formulated for oral delivery.

43 . The pharmaceutical composition of claim 38 wherein the composition is in a capsule or tablet.