IP Library › Patent Application 19418119
Patent Application
App. No. 19/418,119

Antimicrobial Coatings

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Patent No.
US None
App. No.
19/418,119
Abstract

Described are coatings for medical devices and methods of forming same.

Claims (24)

1 . A coating, comprising:

a base coat comprising a copolymer of tetrahydrofurfuryl acrylate and a monomer comprising a functional group amenable to further derivatization, including a plurality of reactive moieties; and

a top coat comprising at least one antimicrobial compound, a polymer, or a combination thereof;

wherein the top coat comprises a copolymer reaction product of a mixture comprising methacryloyloxyethyl phosphorylcholine and 4-hydroxybutyl acrylate, and

wherein the top coat comprises a decorated top coat formed from a reaction product of a mixture comprising the copolymer reaction product and 2-isocyanatoethyl acrylate.

2 . The coating of claim 1 , wherein the top coat comprises a top coat macromer formed from a reaction product of a mixture comprising the decorated top coat, benzophenone, and 1-hydroxycyclohexyl phenyl ketone.

3 . The coating of claim 1 , wherein the functional group comprises at least one of hydroxyl, amine, or carboxylic acid group.

4 . The coating of claim 1 , wherein the monomer comprises hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, hydroxybutyl acrylate, hydroxybutyl methacrylate, N-(3-aminopropyl) methacrylamide, 2-aminoethyl methacrylate, 2-aminoethyl methacrylamide, acrylic acid, methacrylic acid, beta-carboxyethyl acrylate, or a combination thereof.

5 . The coating of claim 1 , wherein the base coat comprises a copolymer of tetrahydrofurfuryl acrylate and 4-hydroxybutyl acrylate.

6 . The coating of claim 5 , wherein the base coat comprises a reaction product of a mixture comprising the copolymer, benzophenone, and 1-hydroxycyclohexyl phenyl ketone.

7 . The coating of claim 1 , wherein said antimicrobial compound comprises an anti-microbial small molecule, protein, polysaccharide, glycosaminoglycan, or polymer derivatized with polymerizable groups.

8 . The coating formulation of claim 1 , wherein said antimicrobial compound comprises at least one of silver-containing polymers, antibiotics, antimicrobial peptides, zwitterionic polymers, nitric oxide releasing polymers, enzymes, extremely hydrophilic polymers, and extremely hydrophobic polymers.

9 . The coating of claim 1 , wherein the structure of the top coat is linear or branched.

10 . A medical device, comprising a surface including the coating of claim 1 .

11 . A medical device, comprising a surface including the coating of claim 2 .

12 . A medical device, comprising a surface including the coating of claim 3 .

13 . A medical device, comprising a surface including the coating of claim 4 .

14 . A medical device, comprising a surface including the coating of claim 5 .

15 . A medical device, comprising a surface including the coating of claim 6 .

16 . A medical device, comprising a surface including the coating of claim 7 .

17 . A medical device, comprising a surface including the coating of claim 8 .

18 . A medical device, comprising a surface including the coating of claim 9 .

19 . The medical device of claim 10 , wherein the medical device is a catheter.

20 . The medical device of claim 19 , wherein the catheter is a urinary catheter.