SYSTEMS, METHODS, AND DEVICES FOR MONITORING AND TREATMENT OF TISSUES WITHIN AND/OR THROUGH A LUMEN WALL
A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. Systems and methods for accessing target tissues as part of a neuromodulation procedure from within a lumen are disclosed.
1 . A tool comprising:
an elongate member comprising a distal tip and a control end, the elongate member configured to extend from an entry site on a body into a lumen within the body;
one or more stabilizing members coupled to the elongate member, the one or more stabilizing members being configured to deploy from the distal tip of the elongate member and to retain a position of the distal tip within a lumen; and
one or more probes coupled with at least one of the distal tip of the elongate member and at least one of the one or more stabilizing members, the one or more probes being configured for deployment responsive to actuation at the control end;
wherein a given one of the probes comprises a probe tip configured to penetrate at least one of into and through the wall of the lumen upon deployment of the given probe; and
wherein the given probe comprises one or more electrodes configured to at least one of monitor and alter electrophysiological activity in the vicinity of the lumen.
2 . The tool of claim 1 , wherein the electrophysiological activity comprises electrophysiological signals related to one or more of water concentration, tissue tone, evoked potential, remotely stimulated nervous activity, sympathetic nervous activity, an electromyographic signal [EMG], a mechanomyographic signal [MMG], a local field potential, an electroacoustic event, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity [MSNA], central sympathetic drive, nerve traffic, or combinations thereof.
3 . The tool of claim 1 , further comprising a microcircuit embedded in the elongate member and coupled to the one or more electrodes of the given probe tip, the microcircuit configured to condition one or more signals conveyed from the one or more electrodes to the control end of the elongate member.
4 . The tool of claim 1 , wherein the one or more electrodes comprise one or more stimulating electrodes configured to provide at least one of a stimulating and ablating current to a tissue site in the vicinity of the wall of the lumen.
5 . The tool of claim 1 , wherein the given probe comprises a channel fluidly coupled with the control end of the elongate member, the channel configured to deliver at least one of a diagnostic and therapeutic substance to a tissue site in the vicinity of the wall of the lumen.
6 . The tool of claim 1 , wherein the given probe comprises a stabilizing element positioned at a predetermined distance from the tip of the given probe, the stabilizing element configured to limit a depth that the given probe penetrates into the wall of the lumen upon deployment from the elongate member.
7 . The tool of claim 1 , wherein the given probe comprises an anchor for securing the given probe to the wall of the lumen upon deployment of the given probe from the elongate member.
8 . The tool of claim 1 , wherein the one or more stabilizing members comprise a plurality of wire members.
9 . The tool of claim 8 , wherein the plurality of wire members have blunt tips, the plurality of wire members being configured to curl outwardly upon deployment from the distal tip of the elongate member to bias against the wall of the lumen without puncturing the wall of the lumen.
10 . The tool of claim 8 , wherein the plurality of wire members comprises a basket catheter.
11 . The tool of claim 10 , further comprising a guiding lumen at the distal tip of the elongate member and a distal portion of the basket catheter.
12 . The tool of claim 11 , further comprising a guidewire configured for advancement and retraction through the guiding lumen.
13 . The tool of claim 8 , wherein the given probe is configured for deployment from a given one of the plurality of wire members.
14 . The tool of claim 13 , wherein the given wire member comprises a channel for communication of a fluid to the probe tip of the given probe.
15 . The tool of claim 1 , wherein the given probe is configured for deployment from the elongate member.
16 . The tool of claim 1 , further comprising one or more additional electrodes arranged on at least one of the one or more stabilizing members, the one or more additional electrodes being configured to at least one of monitor and alter electrophysiological activity in the vicinity of the lumen.
17 . A system comprising:
a tool comprising an elongate member, one or more stabilizing elements coupled to the elongate member, and one or more probes coupled to at least one of a distal tip of the elongate member and at least one of the one or more stabilizing members, the one or more probes being configured for deployment responsive to actuation at a control end of the elongate member, a given one of the probes comprising a probe tip configured to penetrate at least one of into and through a wall of the lumen upon deployment of the given probe, the given probe comprising one or more electrodes; and
a control unit configured to exchange signaling with the control end of the elongate member to direct the one or more electrodes of the given probe to at least one of monitor and alter electrophysiological activity in the vicinity of the lumen.
18 . The system of claim 17 , wherein the control unit is configured to utilizing signaling from the control end of the elongate member to at least one of:
adjust a surgical procedure;
evaluate the surgical procedure;
plan a surgical path for the surgical procedure; and
determine an extent of the surgical procedure.
19 . The system of claim 17 , wherein the one or more electrodes of the given probe comprise one or more sensing electrodes and one or more stimulating electrodes, and wherein the control unit is configured:
to provide signaling to the control end of the elongate member to convey at least one of a pulsatile and a radio frequency signal to an anatomical site via the one or more stimulating electrodes; and
to receive signaling from the control end of elongate member comprising feedback related to the at least one pulsatile and radio frequency signal measured by the one or more sensing electrodes.
20 . The system of claim 17 , wherein the control unit is configured to utilize signaling received from the one or more electrodes via the control end of the elongate member to locate an anatomical site with respect to a position of the tool.