FUNCTIONAL MAGNETIC RESONANCE IMAGING BRAIN MAPPING AND NEUROMODULATION GUIDANCE AND MONITORING BASED THEREON
Functional networks are mapped for individuals and group populations based on magnetic resonance imaging, and the resulting functional mapping data (e.g., probabilistic maps of functional networks and/or integration zones where multiple functional networks overlap and/or interact) are used to guide or otherwise monitor the delivery of neuromodulation therapies. Individual-specific functional network maps can be generated based on an overlapping template matching that is capable of assigning multiple networks to a given grayordinate.
1 . A method for guiding a delivery of neuromodulation to a subject's brain, the method comprising:
(a) accessing a probabilistic functional mapping data with a computer system, wherein the probabilistic functional mapping data comprises at least one of a probabilistic functional network map or a probabilistic integration zone map;
(b) determining one or more target locations in the probabilistic functional mapping data using the computer system, wherein the one or more target locations indicate locations to which neuromodulation should be delivered; and
(c) localizing the one or more target locations relative to the brain of the subject, thereby guiding delivery of the neuromodulation to the one or more target locations.
2 . The method of claim 1 , wherein localizing the one or more target locations relative to the brain of the subject comprises:
accessing medical image data of the subject using the computer system, wherein the medical image data depict the brain of the subject;
coregistering the probabilistic functional mapping data with the medical image data, thereby coregistering the one or more target locations with anatomical locations depicted in the medical image data.
3 . The method of claim 2 , wherein the medical image data comprise magnetic resonance images.
4 . The method of claim 1 , wherein the probabilistic functional mapping data comprise a probabilistic functional network map that indicates probabilities of grayordinates being assigned to one or more particular functional networks.
5 . The method of claim 1 , wherein the probabilistic functional mapping data comprise a probabilistic integration zone map that indicates probabilities of grayordinates being assigned to one or more particular integration zones.
6 . The method of claim 1 , wherein the one or more target locations are determined by selecting grayordinates in the probabilistic functional mapping data having a probability of being associated with a particular functional network that is above a threshold value.
7 . The method of claim 6 , wherein the particular functional network is a functional network associated with a condition to be treated via the neuromodulation.
8 . The method of claim 1 , wherein the one or more target locations are determined by selecting grayordinates in the probabilistic functional mapping data having a probability of being associated with a particular functional network identified as being effectively modulated by the neuromodulation therapy in a group of patients having a same condition as a condition of the subject to be treated via the neuromodulation.
9 . The method of claim 1 , further comprising delivering neuromodulation to the one or more target locations using a neurostimulation device.
10 . The method of claim 9 , wherein the neurostimulation device is a transcranial magnetic stimulation device.
11 . The method of claim 9 , wherein the neurostimulation device is a transcranial direct current stimulation device.
12 . The method of claim 9 , wherein the neurostimulation device is a transcranial alternating current stimulation device.
13 . The method of claim 9 , wherein the neurostimulation device comprises at least one implanted electrode.
14 . The method of claim 1 , wherein the neuromodulation comprises a pharmacological-based neuromodulation.