Sulcardine Salts
Sulcardine salts other than sulfuric acid salts of sulcardine, including crystalline sulcardine salts, are provided herein. Pharmaceutical compositions comprising such salts and methods of treating arrhythmias comprising administering effective amounts of such salts are also provided.
1 . A solid form comprising an acid salt of sulcardine, wherein the acid is hydrobromic acid.
2 . The solid form of claim 1 , which is crystalline.
3 . The solid form of claim 2 , characterized by an XRPD pattern comprising peaks at approximately 17.9, 19.7, and 24.0° 2θ.
4 . The solid form of claim 3 , wherein the XRPD pattern further comprises peaks at approximately 14.1° 2θ.
5 . The solid form of claim 4 , wherein the XRPD pattern further comprises peaks at approximately 5.7, 13.0, and 16.2° 2θ.
6 . The solid form of claim 1 , characterized by an XRPD pattern that matches the XRPD pattern presented in FIG. 23 .
7 . A pharmaceutical composition comprising a solid form of an acid salt of sulcardine, wherein the acid is hydrobromic acid, and one or more pharmaceutically acceptable excipients.
8 . A method of treating arrhythmia, comprising administering to a subject in need thereof a therapeutically effective amount of a solid form of an acid salt of sulcardine, wherein the acid is hydrobromic acid.
9 . The method of claim 8 , wherein the arrhythmia is atrial fibrillation, supraventricular tachyarrhythmia, premature ventricular contraction, ventricular tachycardia, or ventricular fibrillation.
10 . The method of claim 8 , wherein the solid form is in a pharmaceutical composition.