SYSTEMS AND METHODS FOR ACCURATE AND REPEATABLE DELIVERY OF ACTIVE PHARMACEUTICAL INGREDIENTS
This present disclosure provides reliable methods and apparatus for delivering microdroplets containing an active pharmaceutical ingredient (API) to underlying substrates. A control system is provided to ensure that the API dosage is both accurate and repeatable.
1 . A method of limiting error rates in an API dosing system, the method comprising the steps of:
delivering microdroplets of a liquid successively from at least one dosing head to a substrate along a path, wherein the liquid contains a quantity of active pharmaceutical ingredient;
imaging the successively delivered microdroplets at a location between the at least one dosing head and the substrate along the path; and
based on the imaging step, determining a total volume of the liquid that has been delivered to the substrate.