IP Library › Granted Patent US 6,890,747
Granted Patent B2
US 6,890,747 · App. 09/974,573 · Granted May 10, 2005

Phosphoinositide 3-kinases

Assignees: Warner-Lambert Company; Onyx Pharmaceuticals, Inc.
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Quick Facts
Patent No.
US 6,890,747
App. No.
09/974,573
Granted
May 10, 2005
Kind
B2
Abstract

The present invention relates PI3K crystals, polypeptide muteins, polypeptide fragments, antibodies thereto, nucleic acids coding for these polypeptides, methods of modifying PI3Kγ activity, and methods of modulating PI3Kγ activity. These include polypeptides and methods thereof, relating to, e.g., phospholipid binding, lipid kinase activity, modulating Ras activity in activating the PI3Kγ, binding of PI3Kγ to cell membranes, and modulating protein—protein interactions with PI3Kγ.

Claims (1)

1. A crystal of a PI3Kγ catalytic domain, as set forth by residues 144-1102 of SEQ ID NO: 1, wherein the crystal has unit dimensions of a=143.3 Å, b=67.6 Å, c=107.0 Å, and β=95.9°.

Continuity (2)
Provisional Application 6024280100 · Oct 23, 2000
Related Publication 20030022344A1 · Jan 30, 2003