Pharmaceutical preparations of glutathione and methods of administration thereof
A method of increasing glutathione levels in mammalian cells comprising administering an oral bolus of encapsulated pharmaceutically stabilized glutathione in a rapidly dissolving formulation to a mammal on an empty stomach. Pharmaceutical formulations including glutathione are also disclosed.
1. An pharmaceutical formulation, comprising Glutathione, in combination with an effective amount of one or more of a pharmaceutically acceptable physiologic nitric oxide precursor, and an antimicrobial composition.
2. The formulation according to claim 1 , wherein the formulation acts as a vasodilator through alteration of nitric oxide metabolism.
3. The formulation according to claim 1 , wherein the formulation is effective for treating pathological vasospasm.
4. The formulation according to claim 1 , wherein the formulation is effective for treating sexual dysfunction.
5. The formulation according to claim 1 , in combination with a drug effective to treat congestive heart failure.
6. The formulation according to claim 1 , wherein said formulation is in unit dosage form and comprises in physiologic nitric oxide precursor.
7. The formulation according to claim 6 , wherein the nitric oxide precursor is arginine.
8. The formulation according to claim 6 , wherein said formulation comprises about 500 mg reduced L-glutathione, about 200 mg ascorbic acid, and about 200 mg arginine.
9. The formulation according to claim 1 , wherein the formulation comprises a nitric oxide precursor and an antiviral composition.
10. The formulation according to claim 1 , wherein the nitric oxide precursor comprises an NO 2 functionality.
11. The formulation according to claim 10 , wherein the nitric oxide precursor comprises an organic nitrate.
12. The formulation according to claim 1 , wherein said formulation comprises a pharmacutically acceptable antimicrobial antibiotic agent.
13. The formulation according to claim 1 , wherein said antimicrobial compostion comprises an antimicrobial having activity against mycoplasma infection.
14. The formulation according to claim 1 , wherein said antimicrobial agent comprises an antibiotic in sufficient amount to suppress growth of a microbe and said glutathione is provided in sufficent amount to control free radical reactions associated with the microbe.
15. The pharmaceutical formulation according to claim 1 , wherein said formulation is provided in an oral dosage form.
16. The formulation according to claim 1 , wherein said antimicrobial compostion comprises an aminoglycoside.
17. The formulation according to claim 1 , wherein said antimicrobial compostion comprises a quinolone antibiotic.
18. The formulation according to claim 1 , wherein said formulation is adaptcd to modify vascular tone in an organism administered said formulation.
19. A pharmaccutical composition comprising in combination glutathione, or a pharmaccutically acceptable salt or derivative thereof, and an antiviral or antimicrobial antibiotic agent, said glutathione being present in an effective amount to at least one of: serve as an efffective antioxidant agent; supplement endogenous glutathione consumed as a result of administration of the pharmaccutical composition; alter cardiovascular status of a host; alter a redox status of a bost; and alter a gene expression within a host, and said antimicrobial agent being present in an effective amount to treat or prophylax a microbial-associated condition of the host.
20. The pharmaceutical composition according to claim 19 , comprising, in unit dosage form, glutathione in an amount of at least 250 mg., a sacrificial antioxidant to preserve the glutathione in a reduced state, an effective amount of a pharmaceutically acceptable topoisomerase inhibitor, and a pharmaceutically acceptable physiologic nitric oxide precursor.
21. The pharmaceutical composition according to claim 19 , wherein the antioxidant comprises ascorbic acid.
22. The pharmaceutical composition according to claim 19 , further comprising an antibiotic having activity against mycoplasma infection.
23. The pharmaceutical composition according to claim 19 , wherein said composition is provided in an oral dosage form.
24. The pharmaceutical composition according to claim 19 , comprising an aminoglycoside antibiotic.
25. The pharmaceutical composition according to claim 19 , comprising a quinolone antibiotic.