Synthetic peptides for demyelinating conditions
View Patent ↗The invention provides peptide compositions and methods of making and using therapeutic compositions comprising peptides for the treatment of a subject having a demyelinating condition.
1. A composition comprising a synthetic peptide having an amino acid sequence selected from the group consisting of:
EAAKYEAYKAAAAAA,
(SEQ ID NO: 64)
EKAKYEAYKAAAAAA,
(SEQ ID NO: 65)
EAKKYEAYKAAAAAA,
(SEQ ID NO: 66)
EAPKYEAYKAAAAPA,
(SEQ ID NO: 84)
EAPKYEAYKAAAAPA,
(SEQ ID NO: 86)
APEKAKYEAYKAAAAAA,
(SEQ ID NO: 88)
APEKAKYEAYKAAAAAAPA,
(SEQ ID NO: 89)
EKAKYEAYKAAAAAAPA,
(SEQ ID NO: 90)
EKPKFEAYKAAAAPA,
(SEQ ID NO: 91)
EKPKVEAYKAAAAPA,
(SEQ ID NO: 93)
EKAKFEAFKAAAAAA,
(SEQ ID NO: 95)
APEKAKFEAEKAAAAPA,
(SEQ ID NO: 96)
and
APEKAKFEAYKAAAAPA,
(SEQ ID NO: 97).
2. The composition of claim 1 , wherein the peptide is substantially pure.
3. The composition of claim 1 , wherein the peptide comprises an oligomer having a plurality of monomer units having the amino acid sequence of the synthetic peptide, the units joined by a flexible linker.
4. A kit comprising at least one container having a peptide as shown in claim 1 , in a pharmaceutically acceptable buffer, and instructions for use.