Cyclooctanone derivatives and cyclodecanone derivative, and use thereof

1. A compound represented by the following general formula (I) wherein A represents a five- to fourteen-membered aromatic group, which may be substituted, or a cycloaliphatic hydrocarbon group, which may be substituted, having from three to ten carbon atoms;

the partial structure -D---E- represents a group represented by —CH 2 CH 2 — or —CH═CH—;

W represents a group represented by —CH 2 —, —CH 2 CH 2 —, —CH═CH— or —CH═; the partial structure >X---Y— represents a group represented by the formula >CH—(CH 2 ) n —, wherein n is an integer of 0 or 1; >C═CH—; >CH—CH 2 —CH(OH)—; >CH—CH 2 —C(═O)—; >CH—O—; or >CH—O—CO—, provided that when W is —CH═CH—, then X---Y— represents the formula C—(CH 2 ) p —, wherein p is an integer of 0 or 1;

Z represents a divalent aliphatic hydrocarbon group having from zero to eight carbon atoms;

R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, a hydroxyl group, a C 1-6 alkoxy group or a C 1-6 alkoxy-C 1-6 alkoxy group, provided that when R 2 represents a hydrogen atom, R 1 also represents a hydrogen atom;

m is an integer of 0 or 1, and when W represents —CH 2 — or —CH═, then m is 0, and when W represents —(CH 2 ) 2 — or —CH═CH—, then m is 1;

with exception of the compound represented by the following formulae X or Y; or salts thereof or hydrates thereof:

2. The compound according to claim 1 , wherein A is a five- to fourteen-membered aromatic heterocyclic group, which may be substituted; or salts thereof or hydrates thereof.

3. The compound according to claim 1 , wherein A is a phenyl, naphthyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thienyl, furyl, oxazolyl or thiazolyl group, each of which may be substituted; or salts thereof or hydrates thereof.

4. The compound according to claim 1 , wherein A is a phenyl or pyridyl group, each of which may be substituted; or salts thereof or hydrates thereof.

5. The compound according to claim 1 , wherein R 2 and/or R 1 are a hydroxyl group; or salts thereof or hydrates thereof.

6. The compound according to claim 1 , wherein R 1 and/or R 2 are a C 1-6 alkoxy-C 1-6 alkoxy group; or salts thereof or hydrates thereof.

7. The compound according to claim 1 , wherein the partial structure -D---E- represents —CH═CH—; or salts thereof or hydrates thereof.

8. The compound according to claim 1 , wherein W represents —CH 2 — or —CH═, and wherein m is 0; or salts thereof or hydrates thereof.

9. The compound according to claim 1 , wherein W represents —(CH 2 ) 2 — or —CH═CH—, and wherein m is 1; or salts thereof or hydrates thereof.

10. The compound according to claim 1 , wherein the partial structure >X---Y— represents the formula >CH—(CH 2 ) n — (wherein n is an integer of 0 or 1), the formula >C═CH—, the formula >CH—CH 2 —CH(OH)—, the formula >CH—CH 2 —C(═O)— or the formula >CH—O—; or salts thereof or hydrates thereof.

11. The compound according to claim 1 , wherein the partial structure >X---Y— represents >CH—(CH 2 ) n — (wherein n is an integer of 0 or 1); or salts thereof or hydrates thereof.

12. The compound according to claim 1 , wherein A is an aromatic or cycloaliphatic group which may have one to three groups selected from a hydroxyl group or an alkoxy group which may be substituted; or salts thereof or hydrates thereof.

13. The compound according to claim 1 , wherein the compound is selected from the group consisting of 5-benzyl-1-cyclooctanone, 5-phenethyl-1-cyclooctanone, 5-(2-pyridylmethyl)-1-cyclooctanone, 5-[2-(2-hydroxyphenyl)ethyl]-1-cyclooctanone, 5-[2-(2-hydroxy-4-methoxyphenyl)ethyl]-1-cyclooctanone, 5-benzyl-2-cycloocten-1-one, 5-phenethyl-2-cycloocten-1-one, 5-(2-pyridylmethyl)-2-cycloocten-1-one, 5-[2-(2-hydroxy-4-methoxyphenyl)ethyl]-2-cycloocten-1-one, 5-benzyl-8-hydroxy-2-cycloocten-1-one, 5-benzyl-7,8-dihydroxy-2-cycloocten-1-one, 2,3-dihydroxy-5-[2-(2-hydroxyphenyl)ethyl]-1-cyclooctanone, 5-oxocyclooctyl benzoate, 5-oxo-3-cyclooctenyl benzoate, 5-oxocyclooctyl 2-hydroxybenzoate, 5-oxo-3-cyclooctenyl 2-hydroxybenzoate, 5-oxo-3-cyclooctenyl (2-methoxymethoxy)benzoate, 5-oxocyclooctyl (2-hydroxy-4-methoxy)benzoate, 5-oxo-3-cyclooctenyl (2-hydroxy-4-methoxy)benzoate, 5-oxo-3-cyclooctenyl 2-nitrobenzoate, 3,4-dihydroxy-5-oxocyclooctyl benzoate, 6,7-dihydroxy-5-oxo-3-cyclooctenyl benzoate, 6,7-dihydroxy-5-oxo-3-cyclooctenyl 2-hydroxybenzoate, 3,4-dihydroxy-5-oxocyclooctyl (2-methoxymethoxy)benzoate, 3,4-dihydroxy-5-oxocyclooctyl (2-hydroxy-4-methoxy)benzoate, 6,7-dihydroxy-5-oxo-3-cyclooctenyl (2-hydroxy-4-methoxy)-benzoate, 6,7-dihydroxy-5-oxo-3-cyclooctenyl 2-nitrobenzoate, 6-benzyl-1-cyclodecanone, 6-phenethyl-1-cyclodecanone, 6-(2-pyridylmethyl)-1-cyclodecanone, 6-[2-(2-hydroxyphenyl)ethyl]-1-cyclodecanone, 6-[2-(2-hydroxy-4-methoxyphenyl)ethyl]1-cyclodecanone, 6-benzyl-2-cyclodecen-1-one, 6-phenethyl-2-cyclodecen-1-one, 6-(2-pyridylmethyl)-2-cyclodecen-1-one, 6-[2-(2-hydroxy-4-methoxyphenyl)ethyl]-2-cyclodecen-1-one, 6-benzyl-10-hydroxy-2-cyclodecen-1-one, 6-benzyl-9,10-dihydroxy-2-cyclodecen-1-one, 9,10-dihydroxy-6-phenethyl-cyclodecen-1-one, 9,10-dihydroxy-6-[2-(2-hydroxyphenyl)ethyl]cyclodecen-1-one, 6-oxocyclodecyl benzoate, 6-oxo-4-cyclodecenyl benzoate, 6-oxocyclodecyl 2-hydroxybenzoate, 6-oxo-4-cyclodecenyl 2-hydroxybenzoate, 6-oxo-4-cyclodecenyl 4-methoxybenzoate, 6-oxocyclodecyl (2-hydroxy-4-methoxy)benzoate, 6-oxo-4-cyclodecenyl (2-hydroxy-4-methoxy)benzoate, 6-oxocyclodecyl 2-nitrobenzoate, 6-oxo-4-cyclodecenyl 2-nitrobenzoate, 4,5-dihydroxy-6-oxocyclodecyl benzoate, 7,8-dihydroxy-6-oxo-4-cyclodecenyl benzoate, 7,8-dihydroxy-6-oxo-4-cyclodecenyl (2-methoxymethoxy)-benzoate, 7,8-dihydroxy-6-oxo-4-cyclodecenyl 4-methoxybenzoate, 7,8-dihydroxy-6-oxo-4-cyclodecenyl (2-hydroxy-4-methoxy)-benzoate, 4,5-dihydroxy-6-oxocyclodecyl 2-nitrobenzoate, and 7,8-dihydroxy-6-oxo-4-cyclodecenyl 2-nitrobenzoate; and salts thereof or hydrates thereof.

14. A pharmaceutical composition comprising the compound according to claim 1 or salts thereof or hydrates thereof and a pharmaceutically acceptable carrier.