IP Library › Granted Patent US 6,998,469
Granted Patent B2
US 6,998,469 · App. 10/446,826 · Granted Feb 14, 2006

Platelet membrane glycoprotein VI (GPVI) DNA and protein sequences, and uses thereof

Assignee: Otsuka America Pharmaceutical, Inc.
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Quick Facts
Patent No.
US 6,998,469
App. No.
10/446,826
Granted
Feb 14, 2006
Kind
B2
Abstract

The present invention comprises a method of purifying GPVI, GPVI peptides, cDNA and protein sequence, and methods for using GPVI and antibodies directed against GPVI.

Claims (3)

1. A monoclonal antibody which specifically binds with peptide KPSLQALPSSLVPLEK (SEQ ID NO: 18).

2. A monoclonal antibody which specifically binds to SEQ ID NO: 5, wherein the antibody inhibits collagen-induced ATP secretion and human platelet aggregation, wherein the antibody is bivalent.

3. A monoclonal antibody which specifically binds to SEQ ID NO: 5, wherein the antibody inhibits human platelet aggregation but does not inhibit collagen-induced ATP secretion, wherein the antibody is bivalent.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 16, 2006
From: OTSUKA AMERICA PHARMACEUTICAL INC.
To: OTSUKA PHARMACEUTICAL CO., LTD.
Reel/Frame 017906/0210 →
Continuity (4)
Continuation 0965325500 · Aug 31, 2000
Provisional Application 6015219700 · Sep 1, 1999
Provisional Application 6015825100 · Oct 8, 1999
Related Publication 20040152628A9 · Aug 5, 2004