Soft tissue substitute and method of soft tissue reformation
A soft tissue implant material is formed from biologically-compatible polymeric particles. The particles may have a diameter of up to about 500 microns and intraparticulate pores sized for ingrowth of soft tissue. The particles may have an inner core of a first biologically-compatible polymeric material and an outer layer generally surrounding the inner core, with the outer layer comprised of a second biologically-compatible polymeric material being hydrophilic and having a composition different from the composition of the first polymeric material. The material may be utilized with collagen or other matrix materials. This material may be used in a method of reforming soft tissues by implanting the material within soft body tissues to modify soft tissue defects such as wrinkles or oral gingival tissue defects and reshape soft tissue, e.g., for urinary bladder inconvenience.
1. A soft tissue implant material comprising biologically-compatible non-resorbable polymeric particles having a coating of calcium hydroxide thereon, wherein said particles have interstices therebetween having dimensions effective to permit soft tissue to grow therein.
2. The implant material of claim 1 , wherein the particles have intraparticulate pores, said pores having dimensions effective to permit soft tissue to grow therein.
3. Implant material of claim 1 wherein said particles have a diameter of up to about 500 microns.
4. Implant material of claim 3 wherein said particles have a diameter of about 50 to about 200 microns.
5. Implant material of claim 2 wherein said pores comprise up to about 60 percent of said implant material.
6. Implant material of claim 5 wherein said pores comprise between about 40 and about 60 percent of said implant material.
7. Implant material of claim 2 wherein said pores have a size of less than about 100 microns.
8. Implant material of claim 7 wherein said pores have a size of between about 50 and about 100 microns.
9. Implant material of claim 1 further comprising collagen.
10. Implant material of claim 9 wherein said collagen comprises between about 30% and about 65% of said implant material by volume.
11. Implant material of claim 10 wherein said collagen comprises about 50% of said implant material by volume.
12. Implant material of claim 9 wherein said collagen comprises injectable collagen.
13. Implant material of claim 1 wherein said particles have an inner core comprised of a first biologically-compatible polymeric material and an outer layer generally surrounding said inner core, said outer layer comprised of a second biologically-compatible polymeric material, said second polymeric material being hydrophilic and having a composition different from the composition of said first polymeric material.
14. Implant material of claim 13 wherein said first polymeric material is an acrylic polymer.
15. Implant material of claim 14 wherein said first polymeric material is polymethylmethacrylate.
16. Implant material of claim 13 wherein said second polymeric material is a polymeric hydroxyethylmethacrylate.
17. Implant material of claim 16 wherein said polymeric hydroxyethylmethacrylate comprises a copolymer of monomeric hydroxyethylmethacrylate and a cross-linking agent.
18. Implant material of claim 1 further comprising at least one bioactive substance.
19. Implant material of claim 18 wherein said at least one bioactive substance is grafted to said biologically-compatible particles.
20. A particulate soft tissue implant comprising the material of claim 1 .
21. A particulate soft tissue implant comprising particles having an inner core comprised of polymethylmethacrylate and an outer layer generally surrounding said inner core comprised of polymeric hydroxyethylmethacrylate, said particles having interstices therebetween with dimensions effective to permit soft tissue to grow therein.
22. The implant of claim 21 , wherein said particles have intraparticulate pores with dimensions effective to permit soft tissue to grow therein.
23. Implant of claim 22 wherein said pores comprise up to about 60 percent of said implant material.
24. Implant of claim 23 wherein said pores comprise between about 40 and about 60 percent of said implant material.
25. Implant of claim 22 wherein said pores have a size of less than about 100 microns.
26. Implant of claim 25 wherein said pores have a size of between about 50 and about 100 microns.
27. Implant of claim 21 wherein said particles have a diameter of up to about 500 microns.
28. Implant of claim 27 wherein said particles have a diameter of about 50 to about 200 microns.
29. Implant of claim 21 further comprising collagen.
30. Implant of claim 29 wherein said collagen comprises between about 30% and about 65% of said implant material by volume.
31. Implant of claim 30 wherein said collagen comprises about 50% of said implant material by volume.
32. Implant of claim 29 wherein said collagen comprises injectable collagen.
33. Implant of claim 21 further comprising at least one bioactive substance.
34. Implant of claim 33 wherein said at least one bioactive substance is grafted to said biologically-compatible particles.
35. A soft tissue implant material comprising at least partially non-resorbable biologically-compatible polymeric particles having a coating of calcium hydroxide thereon, wherein said particles have interstices therebetween having dimensions effective to permit soft tissue to grow therein.
36. A particulate soft tissue implant comprising the material of claim 35 .
37. A soft tissue implant material comprising at least partially non-resorbable biologically-compatible polymeric particles having an amount of calcium hydroxide thereon effective to induce soft tissue growth, wherein said particles have interstices therebetween having dimensions effective to permit soft tissue to grow therein.
38. A particulate soft tissue implant comprising the material of claim 37 .
39. Implant material of claim 36 , wherein the biologically-compatible polymeric particles are non-resorbable.