IP Library › Granted Patent US 7,026,482
Granted Patent B2
US 7,026,482 · App. 10/974,258 · Granted Apr 11, 2006

Process for preparing imidazoquinolinamines

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Quick Facts
Patent No.
US 7,026,482
App. No.
10/974,258
Granted
Apr 11, 2006
Kind
B2
Abstract

A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.

Claims (6)

1. A compound of Formula VI

wherein R 1 is selected from the group consisting of hydrogen, alkyl of one to about six carbon atoms, hydroxyalkyl wherein the alkyl moiety contains one to about 6 carbon atoms, and arylalkyl wherein the alkyl moiety contains one to about three carbon atoms; R 2 is selected from the group consisting of hydrogen, alkyl of one to about four carbon atoms, alkoxyalkyl wherein the alkoxy moiety contains one to about four carbon atoms and the alkyl moiety contains one to about four carbon atoms, hydroxyalkyl wherein the alkyl moiety contains one to about four carbon atoms, haloalkyl wherein the alkyl moiety contains one to about four carbon atoms, and aiyloxymethyl; and R is hvdrogen.

2. A compound according to claim 1 wherein R 1 is selected from the group consisting of hydrogen, 2-methylpropyl, 2-hydroxy-2-methylpropyl, benzyl and phenylethyl.

3. A compound according to claim 1 wherein R 2 is selected from the group consisting of hydrogen, methyl, ethoxymethyl, and benzyl.

4. A compound according to claim 1 wherein R 1 is 2-methyipropyl, and R 2 is hydrogen.

5. A compound according to claim 1 wherein R 1 is hydrogen, and R 2 is hydrogen.

Assignments (13)
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
NOTICE OF SUCCESSION OF AGENCY Recorded Jan 9, 2015
From: GOLDMAN SACHS LENDING PARTNERS, LLC
To: BARCLAYS BANK PLC, AS SUCCESSOR AGENT
Reel/Frame 034749/0689 →
SECURITY AGREEMENT Recorded Apr 24, 2013
From: MEDICIS PHARMACEUTICAL CORPORATION
To: GOLDMAN SACHS LENDING PARTNERS LLC
Reel/Frame 030281/0433 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2011
From: GRACEWAY PHARMACEUTICALS, LLC
To: MEDICIS PHARMACEUTICAL CORPORATION
Reel/Frame 027370/0813 →
SECOND LIEN GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS AND TRADEMARKS Recorded May 11, 2007
From: GRACEWAY PHARMACEUTICALS, LLC; CHESTER VALLEY PHARMACEUTICALS, LLC
To: DEUTSCHE BANK TRUST COMPANY AMERICAS, AS SECOND LIEN COLLATERAL AGENT
Reel/Frame 019280/0054 →
RELEASE OF SECOND LIEN SECURITY AGREEMENT IN PATENTS Recorded May 10, 2007
From: BANK OF AMERICA, N.A.
To: GRACEWAY PHARMACEUTICALS, LLC; CHESTER VALLEY PHARMACEUTICALS, LLC
Reel/Frame 019265/0704 →
RELEASE OF FIRST LIEN SECURITY AGREEMENT IN PATENTS Recorded May 10, 2007
From: BANK OF AMERICA, N.A.
To: GRACEWAY PHARMACEUTICALS, LLC; CHESTER VALLEY PHARMACEUTICALS, LLC
Reel/Frame 019265/0696 →
FIRST LIEN GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS AND TRADEMARKS Recorded May 10, 2007
From: GRACEWAY PHARMACEUTICALS, LLC; CHESTER VALLEY PHARMACEUTICALS, LLC
To: BANK OF AMERICA, N.A., AS FIRST LIEN COLLATERAL AGENT
Reel/Frame 019265/0712 →
SECOND LIEN GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS AND TRADEMARKS Recorded Mar 23, 2007
From: GRACEWAY PHARMACEUTICALS, LLC; CHESTER VALLEY PHARMACEUTICALS, LLC
To: BANK OF AMERICA, N.A., AS SECOND LIEN COLLATERAL AGENT
Reel/Frame 019055/0032 →
FIRST LIEN GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS AND TRADEMARKS Recorded Mar 21, 2007
From: GRACEWAY PHARMACEUTICALS, LLC; CHESTER VALLEY PHARMACEUTICALS, LLC
To: BANK OF AMERICA, N.A., AS FIRST LIEN COLLATERAL AGENT
Reel/Frame 019035/0859 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2007
From: 3M COMPANY
To: GRACEWAY PHARMACEUTICALS, LLC
Reel/Frame 018917/0665 →
MERGER Recorded Feb 22, 2007
From: MINNESOTA MINING AND MANUFACTURING COMPANY
To: 3M COMPANY
Reel/Frame 018917/0659 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 19, 2007
From: GERSTER, JOHN F.; LINDSTROM, KYLE J.
To: MINNESOTA MINING AND MANUFACTURING COMPANY
Reel/Frame 018902/0543 →
Continuity (8)
Continuation 1062401400 · Jul 21, 2003
Continuation 1036021000 · Feb 6, 2003
Division 1018067800 · Jun 26, 2002
Division 0967819200 · Oct 4, 2000
Division 0937558700 · Aug 17, 1999
Division 0906140100 · Apr 16, 1998
Continuation 0867371200 · Jun 21, 1996
Related Publication 20050096470A1 · May 5, 2005