IP Library › Granted Patent US 7,033,816
Granted Patent B1
US 7,033,816 · App. 10/199,229 · Granted Apr 25, 2006

Activators of cyclin-dependent kinases

Assignee: University of Florida Research Foundation, Inc.
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Quick Facts
Patent No.
US 7,033,816
App. No.
10/199,229
Granted
Apr 25, 2006
Kind
B1
Abstract

A new gene family involved in cell cycle regulation was discovered. This family has been termed activators of cyclin-dependent kinases (ACDKs). A number of ACDK genes have been cloned and sequenced. Proteins encoded by ACDK genes specifically were shown to interact with CDKs and pRb, and to upregulate the kinase activity of a CDK using pRb as a substrate. Progression of a cell through the cell cycle can be regulated by modulating ACDK expression in the cell.

Claims (6)

1. A purified nucleic acid comprising a nucleotide sequence that encodes a native activator of cyclin-dependent kinase (ACDK) consisting of SEQ ID NO:9.

2. The nucleic acid of claim 1 , wherein the nucleotide sequence is SEQ ID NO:1.

3. A vector comprising the nucleic acid of claim 1 .

4. The vector of claim 3 , wherein said nucleic acid is operably linked to one or more expression control sequences.

5. A cell comprising the nucleic acid of claim 1 .

6. The cell of claim 5 , wherein the nucleic acid is comprised in a vector.

Assignments (3)
CONFIRMATORY LICENSE Recorded Sep 22, 2015
From: UNIVERSITY OF FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036662/0579 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 14, 2003
From: FLORIDA, UNIVERSITY OF
To: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 014694/0717 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 23, 2002
From: SHE, JIN-XIONG; WANG, CONG-YI; KUMAR, PRADEEP G.
To: FLORIDA, UNIVERSITY OF
Reel/Frame 013430/0824 →
Continuity (1)
Provisional Application 6030683500 · Jul 19, 2001