Nucleic acids encoding PRO1184 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
1. An isolated nucleic acid comprising:
(a) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:270;
(b) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:270, lacking its associated signal peptide;
(c) the nucleic acid sequence of SEQ ID NO:269;
(d) the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:269; or
(e) the full-length coding sequence of the cDNA deposited under ATCC accession number 209962;
wherein, the polypeptide encoded by said nucleic acid induces chondrocyte redifferentiation.
2. The isolated nucleic acid of claim 1 comprising a nucleic acid sequence encoding the polypeptide of SEQ ID NO:270.
3. The isolated nucleic acid of claim 1 comprising a nucleic acid sequence encoding the polypeptide of SEQ ID NO:270, lacking its associated signal peptide.
4. The isolated nucleic acid of claim 1 comprising the nucleic acid sequence of SEQ ID NO:269.
5. The isolated nucleic acid of claim 1 comprising the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:269.
6. The isolated nucleic acid of claim 1 comprising the full-length coding sequence of the cDNA deposited under ATCC accession number 209962.
7. A vector comprising the nucleic acid of claim 1 .
8. The vector of claim 7 , wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.
9. An isolated host cell comprising the vector of claim 7 .
10. The host cell of claim 9 , wherein said cell is a CHO cell, an E. coli or a yeast cell.