Indole derivatives as anti-inflammatory agents
This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH 2 —, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents
1. A process for preparing a compound, which comprises:
reacting a compound of general Formula
wherein
R 2 is hydrogen alkyl, alkoxy hydroxy, halo, haloalkyl, nitro, cyano, or —NR 5 R 6 , wherein R 5 and R 6 are each independently hydrogen or alkyl; and
R is lower alkyl,
with a compound of general Formula ArAH, to provide a compound of Formula (I):
wherein A is —S—,
Ar is an optionally substituted phenyl, and
R is lower alkyl.
2. The method of claim 1 , wherein R is methyl.
3. The method of claim 2 , wherein Ar is 4-fluorophenyl.
4. The method of claim 2 , wherein Ar is 4-bromophenyl.
5. The method of claim 2 , wherein Ar is 2,4-difluorophenyl.
6. The method of claim 2 , wherein Ar is 2-chlorophenyl.