Compounds for the treatment of metabolic disorders
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
1. A compound of the formula:
wherein
n is 1 or 2;
m is 0 or 1;
p is 1 and R 1 is ethyl; or p is 2 and R 1 is hydrogen or ethyl;
one of R 2 and R 3 is methyl, methoxy or perfluoromethyl and the other is hydrogen or methyl;
or when R 1 is hydrogen, a pharmaceutically acceptable salt of the compound.
2. The compound or salt of claim 1 , wherein R 2 is methyl, methoxy or perfluoromethyl and R 3 is hydrogen.
3. The compound or salt of claim 2 , wherein the compound is 4-(4-(2-methyoxybenzyloxy)phenyl)-4-oxobutyric acid.
4. The compound or salt of claim 2 , wherein the compound is 4-(4-(2-methylbenzyloxy)phenyl)-4-oxobutyric acid.
5. The compound or salt of claim 2 , wherein the compound is 4-(3-(2-methylbenzyloxy)phenyl)-4-oxobutyric acid.
6. The compound or salt of claim 2 , wherein the compound is Ethyl 4-(4-(2-methylbenzyloxyl)phenyl)-4-oxobutyrate.
7. The compound or salt of claim 2 , wherein the compound is 4-(4-(2-trifluoromethylbenzyloxy)phenyl)-4-oxobutyric acid.
8. The compound or salt of claim 1 , wherein R 2 is methyl and R 3 is methyl.
9. The compound or salt of claim 8 , wherein the compound is 4-(4-(2,5-dimethylbenzyloxy)phenyl)-4-oxobutyric acid.
10. The compound or salt of claim 8 , wherein the compound is 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyric acid.