HFC solution formulations containing an anticholinergic

1. An aerosol solution formulation comprising:

(a) a salt of formula 1

wherein X − is an anion

(b) an HFC propellant;

(c) a cosolvent; and

(d) an inorganic or an organic acid, wherein the concentration of the acid is in a range that corresponds with a pH range of 2.5 to 5.5 in aqueous solution.

2. The aerosol solution formulation according to claim 1 , wherein X − is chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate, or p-toluenesulfonate.

3. The aerosol solution formulation according to claim 1 , wherein the aerosol solution formulation contains 0.0000800% to 400% of the pharmacologically active cation of formula 1′

4. The aerosol solution formulation according to claim 1 , wherein the HFC propellant is HFC-134(a), HFC-227, HFC-32, HFC-143(a), HFC-134, HFC-152a, or a mixture thereof.

5. The aerosol solution formulation according to claim 2 , wherein the HFC propellant is HFC-134(a), HFC-227, HFC-32, HFC-143(a), HFC-134, HFC-152a, or a mixture thereof.

6. The aerosol solution formulation according to claim 3 , wherein the HFC propellant is HFC-134(a), HFC-227, HFC-32, HFC-143(a), HFC-134, HFC-152a, or a mixture thereof.

7. The aerosol solution formulation according to claim 1 , wherein the acid is hydrochloric acid, sulfuric acid, nitric acid, or phosphoric acid.

8. The aerosol solution formulation according to claim 2 , wherein the acid is hydrochloric acid, sulfuric acid, nitric acid, or phosphoric acid.

9. The aerosol solution formulation according to claim 3 , wherein the acid is hydrochloric acid, sulfuric acid, nitric acid, or phosphoric acid.

10. The aerosol solution formulation according to claim 1 , wherein the acid is ascorbic acid, citric acid, lactic acid, malic acid, benzoic acid, or tartaric acid.

11. The aerosol solution formulation according to claim 2 , wherein the acid is ascorbic acid, citric acid, lactic acid, malic acid, benzoic acid, or tartaric acid.

12. The aerosol solution formulation according to claim 3 , wherein the acid is ascorbic acid, citric acid, lactic acid, malic acid, benzoic acid, or tartaric acid.

13. The aerosol solution formulation according to claim 1 , wherein the aerosol solution formulation contains water in an amount of up to about 5%.

14. The aerosol solution formulation according to claim 2 , wherein the aerosol solution formulation contains water in an amount of up to about 5%.

15. The aerosol solution formulation according to claim 3 , wherein the aerosol solution formulation contains water in an amount of up to about 5%.

16. The aerosol solution formulation according to claim 1 , wherein the cosolvent is an alcohol, glycol, glycol ether, block copolymer of oxyethylene and oxypropylene, glycerol, polyoxyethylene alcohol, polyoxyethylene fatty acid ester, or glycofurol.

17. The aerosol solution formulation according to claim 2 , wherein the cosolvent is an alcohol, glycol, glycol ether, block copolymer of oxyethylene and oxypropylene, glycerol, polyoxyethylene alcohol, polyoxyethylene fatty acid ester, or glycofurol.

18. The aerosol solution formulation according to claim 3 , wherein the cosolvent is an alcohol, glycol, glycol ether, block copolymer of oxyethylene and oxypropylene, glycerol, polyoxyethylene alcohol, polyoxyethylene fatty acid ester, or glycofurol.

19. The aerosol solution formulation according to claim 1 , wherein the cosolvent is present in an amount in the range of 5% to 50% (w/w).

20. The aerosol solution formulation according to claim 16 , wherein the cosolvent is present in an amount in the range of 5% to 50% (w/w).

21. The aerosol solution formulation according to claim 17 , wherein the cosolvent is present in an amount in the range of 5% to 50% (w/w).

22. The aerosol solution formulation according to claim 18 , wherein the cosolvent is present in an amount in the range of 5% to 50% (w/w).