Oral compositions comprising a viscosity modifier for reduction of tooth erosion
The use of viscosity modifying polymer materials, commonly used as stabilisers, thickeners and emulsifiers, as tooth erosion inhibitors in acidic compositions for oral administration, especially in acidic beverages such as fruit drinks and oral healthcare products such as mouthwashes, in which the effective pH of the composition is less than or equal to 4.5.
1. A method of reducing tooth erosion caused by acid in orally administered compositions comprising
(i) providing a first acidic orally administrable composition;
(ii) adding to said first acidic orally administrable composition:
(a) a calcium compound present in an amount of 0.01 to 0.75 mol per mole of acid;
(b) a viscosity modulating polymer material which is a polysaccharide selected from the group consisting of an alginate, locust bean gum, gellan gum, guar gum, gum arabic, tragacanth, carrageenin, acacia gum, xanthan gum, pectin, cellulose gum, or a combination or mixture thereof; and
(c) controlling or adjusting the effective pH of the resulting composition to less than or equal to 4.5, and
(iii) thereby providing a second acidic orally administrable composition which has a lower tooth erosion potential than said first acidic orally administrable composition; and
(iv) orally administering said second acidic orally administrable composition to a mammal.
2. The method as claimed in claim 1 wherein the polysaccharide is an alginate, a xanthan gum or a pectin.
3. The method as claimed in claim 1 wherein the effective pH of the composition is from 2.0 to 4.5.
4. The method as claimed in claim 1 wherein the acid in the first or second acidic composition is citric acid, malic acid, lactic acid, tartaric acid, phosphoric acid, acetic acid or a mixture thereof.
5. The method as claimed in claim 1 wherein the calcium compound present in the composition has a molar ratio of calcium to acid from 0.1 to 0.5.
6. The method as claimed in claim 1 wherein the calcium compound is a soluble calcium salt.
7. The method as claimed in claim 1 wherein the second acidic composition is a beverage or a liquid or solid concentrate for the preparation of a beverage.
8. The method as claimed in claim 7 wherein the beverage is a health drink.
9. The method as claimed in claim 1 wherein the second acidic composition is an oral healthcare product.
10. The method as claimed in claim 7 wherein the beverage has a pH in the range 2.5 to 4.0.
11. The method as claimed in claim 7 wherein the beverage has a titratable acidity in the range 0.01 to 4% w/w.
12. A process for preparing an acidic orally administrable composition comprising;
(i) providing a first acidic orally administrable composition;
(ii) adding to said first acidic orally administrable composition:
(a) a viscosity modulating polymer material selected from the group consisting of an alginate, locust bean gum, gellan gum, guar gum, gum arabic, tragacanth, carrageenin, acacia gum, xanthan gum, pectin, cellulose gum, or a combination or mixture thereof;
(b) calcium in the range 0.01 to 0.8 mol per mol of acid;
(c) adjusting or controlling the effective pH provide a composition with an effective pH less than or equal to 4.5;
(iii) thereby providing a second acidic composition which has a lower tooth erosion potential than said first acidic orally administrable composition.
13. A process for preparing an acidic orally administrable composition comprising:
(i) providing a first acidic orally administrable composition;
(ii) adding to said first acidic orally administrable composition:
(a) a viscosity modulating polymer material which is polyvinylpyrrolidone;
(b) calcium in the range 0 to 0.8 mol per mol of acid; and
(c) controlling or adjusting the effective pH to provide a composition with an effective pH less than or equal to 4.5;
(iii) thereby providing a second acidic composition which has a lower tooth erosion potential than said first acidic orally administrable composition.
14. A method of reducing tooth erosion caused by acid in orally administered compositions comprising
(i) providing a first acidic orally administrable composition;
(ii) adding to said first acidic orally administrable composition:
(a) a viscosity modulating polymer material which is polyvinylpyrrolidone;
(b) and optionally adding calcium in the range 0 to 0.8 mol per mol of acid; and
c) controlling or adjusting the effective pH to provide a composition with an effective pH less than or equal to 4.5;
(iii) thereby providing a second acidic composition which has a lower tooth erosion potential than said first acidic orally administrable composition;
(iv) orally administering said second acidic orally administrable composition to a mammal.
15. The method as claimed in claim 1 wherein the polysaccharide is present in an amount of 0.07 to 1.2% w/v.
16. The process as claimed in claim 12 wherein the viscosity modulating polymer material is an alginate, a xanthan or a pectin.
17. The process as claimed in claim 12 wherein the effective pH of the composition is from 2.0 to 4.5.
18. The process as claimed in claim 12 wherein the acid in the first or second acidic composition is citric acid, malic acid, lactic acid, tartaric acid, phosphoric acid, acetic acid or a mixture thereof.
19. The process as claimed in claim 12 wherein the calcium present in the composition has a molar ratio of calcium to acid from 0.1 to 0.5.
20. The process as claimed in claim 12 wherein the calcium present in the composition is a soluble calcium salt.
21. The process as claimed in claim 12 wherein the second acidic composition is a beverage or a liquid or solid concentrate for the preparation of a beverage.
22. The process as claimed in claim 12 wherein the beverage has a titratable acidity in the range 0.01 to 4% w/w.
23. The process as claimed in claim 13 wherein the effective pH of the composition is from 2.0 to 4.5.
24. The process as claimed in claim 13 wherein the acid in the first or second acidic composition is citric acid, malic acid, lactic acid, tartaric acid, phosphoric acid, acetic acid or a mixture thereof.
25. The process as claimed in claim 13 wherein the calcium present in the composition has a molar ratio of calcium to acid from 0.1 to 0.5.
26. The process as claimed in claim 13 wherein the calcium present in the composition is a soluble calcium salt.
27. The process as claimed in claim 13 wherein the second acidic composition is a beverage or a liquid or solid concentrate for the preparation of a beverage.
28. The process as claimed in claim 27 wherein the beverage has a titratable acidity in the range 0.01 to 4% w/w.
29. The method as claimed in claim 14 wherein the effective pH of the composition is from 2.0 to 4.5.
30. The method as claimed in claim 14 wherein the acid in the first or second acidic composition is citric acid, malic acid, lactic acid, tartaric acid, phosphoric acid, acetic acid or a mixture thereof.
31. The method as claimed in claim 14 wherein the calcium present in the composition has a molar ratio of calcium to acid from 0.1 to 0.5.
32. The method as claimed in claim 14 wherein the calcium present in the composition is a soluble calcium salt.
33. The method as claimed in claim 14 wherein the second acidic composition is a beverage or a liquid or solid concentrate for the preparation of a beverage.
34. The method as claimed in claim 33 wherein the beverage is a health drink.
35. The method as claimed in claim 14 wherein the second acidic composition is an oral healthcare product.
36. The method as claimed in claim 35 wherein the beverage has a pH in the range 2.5 to 4.0.
37. The method as claimed in claim 33 wherein the beverage has a titratable acidity in the range 0.01 to 4% w/w.