Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators

1. A compound of the following formula (Ia) or (Ib):

wherein R 1 is independently chosen from halo, haloalkyl, hydroxy, thiol, substituted thiol, sulfonyl, sulfinyl, nitro, cyano, amino, substituted amino, C 1 -C 6 alkyl and C 1 -C 6 alkoxy, and when R 1 is hydroxy, C 1 -C 6 alkoxy, thiol, substituted thiol, amino, substituted amino, or C 1 -C 6 alkyl, such radical may be combined with R 2 to form a ring of 5-7 members when R 1 is ortho to R 2 ;

R 2 is selected from NR 3 C(S)NR 4 R 5 , NR 3 C(═NR 3 )NR 4 R 5 , NR 3 C(═NCN)NR 4 R 5 , NR 3 C(═CHNO 2 )NR 4 R 5 , NR 3 P(O)R 4 R 5 , NR 3 P(O)(OR 4 )(OR 5 ), NR 3 P(O)(OR 4 )(NR 5 ), NR 3 P(O)(NR 4 )(NR 5 ), NR 3 C(═NR 3 )R 6 , COR 6 , R 6 C(OH)R 7 , CR 8 ═NOR 4 , CR 8 ═NR 3 , CR 8 ═NNR 4 R 5 , SOR 7 , SO 2 R 7 , P(O)(OR 4 )(OR 5 ), P(O)(R 4 )(R 5 ), P(O)(OR 4 )(OR 5 ), P(O)(NR 3 )(OR 4 ), P(O)(NR 4 )(NR 5 ), a 3-7 membered ring containing from zero to three heteroatoms selected from O, N, or S, which may be substituted by R 9 , R 10 , R 11 , R 12 or R 13 , with the exception of the following groups:

or may be combined with R 1 to form a ring of 5-7 members when R 1 is ortho to R 2 ;

R 3 is hydrogen, alkyl, aryl, heterocyclyl, acyl, or may form a ring of 5-7 members with R 4 or R 5 ;

R 4 is hydrogen, alkyl, aryl, heterocyclyl, acyl, or may form a ring of 5-7 members with R 5 or R 3 ;

R 5 is hydrogen, alkyl, aryl, or heterocyclyl, acyl or may form a ring of 5-7 members with R 3 or R 4 ;

R 6 and R 7 may be equal or different and are selected from hydrogen, alkyl, aryl, or heterocyclyl;

R 8 is hydrogen, alkyl, aryl, heterocyclyl, amino or substituted amino;

R 9 , R 10 , R 11 and R 12 may be equal or different and are selected from hydrogen, alkyl, aryl, heterocyclyl, nitro, cyano, carboxylic acid, ester, amide, halo, hydroxyl, amino, substituted amino, alkoxy, acyl, ureido, sulfonamido, sulfamido, sulfonyl, sulfinyl, or guanadinyl;

R 13 is hydrogen, alkyl, aryl, heterocyclyl, acyl, ester, sulfonyl, ureido, or guanadinyl;

A is O, S, or NR 3 ;

m is from zero to four;

X is H, CF 2 Z, or CF 3 , or together with Y forms a double bond when A is O;

Y is hydrogen, or together with X forms a double bond when A is O; and

Z is F, Br, Cl, I or CF 3 ;

its corresponding enantiomers, diastereoisomers or tautomers; or a pharmaceutically acceptable salt, or a prodrug thereof.

2. A compound according to Ia as defined in claim 1 having the following structural formulae (Ic and Id):

wherein R 1 is hydrogen, halo, hydroxyl or cyano.

3. A compound according to Ic and Id as defined in claim 2 wherein R 2 is selected from the following formulae:

wherein R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are defined as above.

4. A compound according to Ic and Id as defined in claim 2 wherein R 2 is selected from the following formulae:

wherein R 9 , R 10 , and R 13 are defined as above.

5. A compound according to claim 1 selected from the group consisting of:

3-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-4,5-dihydroisoxazole-5-carboxylic acid;

5-amino-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-4-carbonitrile;

Ethyl 5-pyridin-3-yl-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-4-carboxylate;

Methyl 5-[(methyloxy)methyl]-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-4-carboxylate;

Methyl 3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-4,5-dihydroisoxazole-5-carboxylate;

Diethyl 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl amidophosphate;

Diethyl ethyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amidophosphate;

Diethyl 4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl phosphonate; and

Phenyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}phosphinic acid.

6. The compound of claim 1 , wherein the compound has formula (Ia).

7. The compound of claim 6 , wherein R 2 is NR 3 C(S)NR 4 R 5 or NR 3 C(═NR 3 )NR 4 R 5 .

8. The compound of claim 7 , wherein R 4 and R 5 , and the N atom to which they are attached form a 5-7 membered ring.

9. The compound of claim 8 , wherein R 4 and R 5 , and the N atom to which they are attached form a morpholine ring.

10. The compound of claim 9 , wherein X is CF 3 , A is O, Y is H, and Z is F.

11. The compound of claim 1 , wherein R 2 is NR 3 C(S)NR 4 R 5 or NR 3 C(═NR 3 )NR 4 R 5 .

12. The compound of claim 1 , wherein X is CF 3 , A is O, Y is H, and Z is F.

13. The compound of claim 3 , wherein the compound is selected from the group consisting of:

N-(4-Cyanobutyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl}morpholine-4-carbothioamide;

Methyl 5-((morpholin4-ylcarbonothioyl){4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)pentanoate;

[Bis(1-methylethyl)amino](butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)methaniminium chloride;

(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)(pyrrolidin-1-yl)methaniminium chloride;

(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)(diethylamino)methaniminium chloride;

N-[4-(3-Methyl-1,2,4-oxadiazol-5-yl)butyl]-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}morpholine-4-carbothioamide;

(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)(piperidin-1-yl)methaniminium chloride;

N-[(4-Cyanophenyl)methyl]-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}morpholine-4-carbothioamide;

N-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-N-{[4-(trifluoromethyl)phenyl]methyl}morpholine-4-carbothioamide;

N-[3-(1H-pyrrol-1-yl)propyl]-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}morpholine-4-carbothioamide;

N-Butyl-N′,N′-diethyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}thiourea;

(Dimethylamino)(propyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)methaniminium chloride;

(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)(morpholin-4-yl)methaniminium chloride;

(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)(dibutylamino)methaniminium chloride;

[Bis(1-methylethyl)amino]({4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}amino)methaniminium chloride;

N-Ethyl-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}morpholine-4-carbothioamide;

N,N,1-Trimethyl-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-4,5-dihydro-1H-pyrazole-5-carboxamide;

1,1-Dimethylethyl3-{[(3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-4,5-dihydroisoxazol-5-yl)carbonyl]amino}propanoate;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one O-(2-morpholin4-yl-2-oxoethyl)oxime;

(Z)-Phenyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}methanone O-methyloxime;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}pentan-1-one O-methyloxime;

3-Methyl-1-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one;

1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}pentan-1-one;

2-Methyl-1-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}propan-1-one;

1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one;

(1E)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one O-methyloxime;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one O-ethyloxime;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one oxime;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one O-(1-methylethyl)oxime;

Phenyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}methanone;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one O-[2-(phenyloxy)ethyl]oxime;

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}butan-1-one O-(phenylmethyl)oxime; and

(1Z)-1-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl)butan-1-one O-(2-methylpropyl)oxime.

14. The compound of claim 4 , wherein the compound is selected from the group consisting of:

1-Methyl-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-pyrazole-4-carbonitrile;

1-(1-Phenyl-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-pyrazol-4-yl)ethanone;

Methyl 5-amino-1-phenyl-3-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-pyrazole-4-carboxylate;

1,1,1,3,3,3-Hexafluoro-2-[4-(4-phenyl-1-propyl-1H-imidazol-2-yl)phenyl]propan-2-ol;

1,1,1,3,3,3-Hexafluoro-2-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]phenyl}propan-2-ol;

1,1,1,3,3,3-Hexafluoro-2[4-(4-methyl-1H-imidazol-2-yl)phenyl]propan-2-ol;

(2-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazol-4-yl)methyl2-methylpropanoate; 1,1,1,3,3,3-Hexafluoro-2-[4-(1-propyl-4,5-dipyridin-3-yl-1H-imidazol-2-yl)phenyl]propan-2-ol;

1,1,1,3,3,3-Hexafluoro-2-[4-(4-pyridin-3-yl-1H-imidazol-2-yl)phenyl]propan-2-ol;

N-Butyl-4-phenyl-1-propyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

N-Butyl-4-phenyl-1-pyridin-3-ylmethyl)-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

N-Butyl-1-(2-morpholin-4-ylethyl)4-phenyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

N-Butyl-1-(2-cyanoethyl)-4-phenyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

N-Butyl-1-(3-hydroxypropyl)-4-phenyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

2-[4-(4,5-Diphenyl-1-propyl-1H-imidazol-2-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

N-Butyl-1-(1-methylethyl)-4-phenyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

Methyl{[(4-phenyl-1-propyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazol-5-yl)carbonyl]amino}acetate;

{[(4-Phenyl-1-propyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazol-5-yl)carbonyl]amino}acetic acid;

N-Butyl-1-(2-methylpropyl)-4-phenyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

N-Butyl-1-propyl-4-pyridin-3-yl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

N-[(2-{4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazol-4-yl)methyl]methanesulfonamide;

N-Butyl-4-(4-cyanophenyl)-1-propyl-2-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-imidazole-5-carboxamide;

2-[4-(5-Amino-3-phenyl-1H-pyrazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

2-{4-[5-Amino-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazol-4-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol;

4-(5-Amino-3-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-pyrazol-1-yl)benzonitrile;

Ethyl (5-amino-3-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-1H-pyrazol-1-yl)acetate;

N-(3-(1-Methylethyl)-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)pent-4-enamide;

2-[4-(5-Amino-3-pyridin-4-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

2-Methyl-N-(3-pyridin-4-yl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)propanamide;

(2E)-3-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)prop-2-enenitrile;

N-(3-(1-Methylethyl)-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)pyridine-4-carboxamide;

N-(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)pyridine-4-carboxamide;

4-Cyano-N-(3-(1-methylethyl)-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)benzamide;

2-[4-(3,5-Dimethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

N-(3-(1-Methylethyl)-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)-2-phenylbutanamide;

2-{4-[5-Amino-3-(1-methylethyl)isoxazol-4-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol;

N-(3,5-Dimethylisoxazol-4-yl)-N′-(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)urea;

2-(4-{5-Amino-3-[(ethyloxy)methyl]isoxazol-4-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol;

3-(5-Amino-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)propan-1-ol;

2-[4-(5-Amino-3-butylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

2-[4-(5-Amino-3-ethylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

N,5-Dimethyl-N-(methyloxy)-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-3-carboxamide;

2-Methyl-N-(3-phenyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)propanamide;

1-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)butan-1-one;

Ethyl 5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-3-carboxylate;

2-Methyl-N-(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)propanamide;

N,N,5-Trimethyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-3-carboxamide;

4-[(3-(1-Methylethyl)-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl) ethyl]phenyl}isoxazol-5-yl)amino]-4-oxo-2-phenylbutanoic acid;

1,1,1,3,3,3-Hexafluoro-2-{4-[3-(hydroxymethyl)-5-methylisoxazol-4-yl]phenyl}propan-2-ol;

1,1-Dimethylethyl 5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-ylcarbamate;

2-(4-{5-Amino-3-[(2E)-but-2-enyl]isoxazol-4-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol;

3-(5-Amino-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)propanoic acid;

4-(5-Amino-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)phenol;

Ethyl 4-(methylthio)-2-({[(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)amino]carbonyl}amino)butanoate;

N-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)hexanamide;

Ethyl 4-methyl-2-({[(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)amino]carbonyl}anlino)pentanoate;

({[(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)amino]carbonyl}amino)acetic acid;

N-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)-N′-phenylurea;

2-[4-(5-Amino-3-furan-3-ylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazole-3-carboxylic acid;

N-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)acetamide;

4-(Methylthio)-2-({[(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)amino]carbonyl}amino)butanoic acid;

2-{4-[5-Amino-3-(1H-indol-3-ylmethyl)isoxazol-4-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol;

2-[4-(5-Amino-3-phenylisoxazol-4-yl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol;

N-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)-3-phenylpropanamide;

2-(4-{5-Amino-3-[4-(methyloxy)phenyl]isoxazol-4-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol;

N-(5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)-N′-(2-phenylethyl)urea;

Ethyl (2E)-3-(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)prop-2-enoate;

2-{4-[5-Amino-3-(trifluoromethyl)isoxazol-4-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol;

4-Methyl-2-({[(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)amino]carbonyl}amino)pentanoic acid;

Ethyl ({[(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)amino]carbonyl}amino)acetate;

N-(1-Methylethyl)-N′-(3-phenyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-5-yl)urea;

Bis(1,1-dimethylethyl)5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-ylimidodicarbonate;

N-Cyclohexyl-N′-(5-methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-yl)urea;

2-{4-[5-Amino-3-(phenylmethyl)isoxazol-4-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol; and

5-Methyl-4-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}isoxazol-3-aminium trifluoroacetate.