IP Library › Granted Patent US 7,288,546
Granted Patent B1
US 7,288,546 · App. 10/369,311 · Granted Oct 30, 2007

Method and compound for inhibition of cell death

Assignee: University of Central Florida
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Quick Facts
Patent No.
US 7,288,546
App. No.
10/369,311
Granted
Oct 30, 2007
Kind
B1
Abstract

This invention relates to a chemical compound that inhibits the apoptotic activity of the protease Omi/HtrA2 and homologous proteins. This protease Omi/HtrA2 is present in all mammalian cells so that inhibition of apoptosis in this fashion results enhanced cellular health and therapeutic effects.

Claims (4)

1. A method of inhibiting a protein selected from the group consisting of Omi/HtrA2, L56, and bacterial HtrA comprising reacting the protein with a compound of the formula

2. A method, as in claim 1 , wherein said protein is protein L56.

3. An method, as in claim 1 , wherein said protein is bacterial HtrA.

4. A method, as in claim 1 , wherein said protein is Omi/HtrA2.

Assignments (3)
CONFIRMATORY LICENSE Recorded Aug 23, 2013
From: UNIVERSITY OF CENTRAL FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031076/0079 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2012
From: UNIVERSITY OF CENTRAL FLORIDA
To: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 028526/0720 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2003
From: ZERVOS, ANTONIS S.
To: UNIVERSITY OF CENTRAL FLORIDA
Reel/Frame 013794/0505 →