Thermal surgical procedures and compositions
Methods, compositions, and systems useful to enhance a thermal surgical procedure are described. Compositions include at least one compound effective to induce an inflammatory response in biological material identified to undergo a thermal surgical procedure. Methods and systems include providing compositions of the invention to biological materials and treating biological materials with an inflammation inducing composition for a time, amount, and type effective to induce inflammation in at least a portion of the biological material.
1. A system for inducing inflammation in biological material identified to undergo a thermal surgical procedure, comprising:
a composition comprising at least one compound effective for inducing inflammation in at least a portion of the biological material, wherein the at least one compound is carried in the composition by microbeads and/or nanobeads;
means for delivering the composition to at least a portion of the biological material; and
means effective to remove thermal energy from at least a portion of the biological material at a rate sufficient to cause the biological material to be cooled to a temperature below a physiological temperature of the biological material.
2. The system of claim 1 wherein the composition further comprises a pharmaceutically acceptable carrier.
3. The system of claim 1 wherein the means for delivering the composition comprises a catheter comprising a lumen, and further wherein the composition is capable of being delivered through the lumen of the catheter.
4. The system of claim 1 wherein the means effective to remove thermal energy from at least a portion of the biological material comprises a probe.
5. A system for inducing inflammation in biological material identified to undergo a thermal surgical procedure, comprising:
a composition comprising at least one compound effective for inducing inflammation in at least a portion of the biological material, wherein the at least one compound is carried in the composition by microbeads and/or nanobeads;
means for delivering the composition to at least a portion of the biological material; and
means effective to supply thermal energy to at least a portion of the biological material at a rate sufficient to cause the biological material to be heated to a temperature above a physiological temperature of the biological material.
6. The system of claim 5 wherein the means effective to supply thermal energy to at least a portion of the biological material comprises a probe.
7. The system of claim 5 wherein the composition further comprises a pharmaceutically acceptable carrier.
8. The system of claim 5 wherein the means for delivering the composition comprises a catheter comprising a lumen, and further wherein the composition is capable of being delivered through the lumen of the catheter.
9. A kit for use in a thermal surgical procedure comprising:
a thermal surgical probe adapted to transfer thermal energy; and
a composition comprising at least one compound effective for inducing an inflammatory response in biological material identified to undergo a thermal surgical procedure, wherein the at least one compound is carried in the composition by microbeads and/or nanobeads.
10. The kit of claim 9 wherein the composition comprises a compound selected from the group consisting of at least one virus, at least one bacterium, ethanol, cytokines, interleukins, chemokines, oxygen-free radicals, bacterial lipopolysaccharides, and combinations thereof.
11. The kit of claim 10 wherein the cytokine is selected from the group consisting of TNF-alpha, truncated versions of TNF-alpha, and combinations thereof.
12. The kit of claim 10 wherein the interleukin is selected from the group consisting of IL-beta, IL-8, and combinations thereof.
13. The kit of claim 9 wherein the composition further comprises a pharmaceutically acceptable carrier.
14. The kit of claim 9 wherein the probe comprises a catheter.
15. The kit of claim 9 wherein the probe comprises a hollow needle.
16. The kit of claim 9 wherein the probe comprises a cryoprobe.
17. The kit of claim 9 wherein the probe comprises an implantable device.
18. The kit of claim 9 further comprising means for delivering the composition.
19. The kit of claim 18 wherein the means for delivering the composition is adapted to transfer thermal energy.
20. A system for inducing inflammation in biological material identified to undergo a thermal surgical procedure, comprising:
a composition comprising at least one compound effective for inducing inflammation in at least a portion of the biological material, wherein the composition comprises a compound selected from the group consisting of at least one virus, at least one bacterium, and combinations thereof;
means for delivering the composition to at least a portion of the biological material; and
means effective to remove thermal energy from at least a portion of the biological material at a rate sufficient to cause the biological material to be cooled to a temperature below a physiological temperature of the biological material.
21. A system for inducing inflammation in biological material identified to undergo a thermal surgical procedure, comprising:
a composition comprising at least one compound effective for inducing inflammation in at least a portion of the biological material, wherein the composition comprises a compound selected from the group consisting of at least one virus, at least one bacterium, and combinations thereof;
means for delivering the composition to at least a portion of the biological material; and
means effective to supply thermal energy to at least a portion of the biological material at a rate sufficient to cause the biological material to be heated to a temperature above a physiological temperature of the biological material.
22. A kit for use in a thermal surgical procedure comprising:
a thermal surgical probe adapted to transfer thermal energy; and
a composition comprising at least one compound effective for inducing an inflammatory response in biological material identified to undergo a thermal surgical procedure, wherein the composition comprises a compound selected from the group consisting of at least one virus, at least one bacterium, and combinations thereof.