Fused indazole compounds

1. A compound represented by the following formula, a salt thereof or a hydrate of them

wherein Z 11 and Z 12 each independently represent a carbonyl group, an oxygen atom, a sulfur atom, or a methine group which may be substituted, a methylene group which may be substituted or a nitrogen atom which may be substituted; represents a double bond or a single bond; R 1a represents a hydrogen atom, a C 1 -C 6 alkyl group, a phenyl group or a benzyl group; R 2a , R 2b and R 2c each independently represent a group selected from Substituent Group (a); the ring A represents a benzene ring which may have one to three groups selected from Substituent Group (a), a naphthalene ring which may have one to three groups selected from Substituent Group (a) or a 5- to 10-membered aromatic heterocyclic ring which may have one to three groups selected from Substituent Group (a);

Substituent Group (a)

(1) a hydrogen atom, (2) halogen atoms, (3) a nitro group, (4) a hydroxyl group, (5) a cyano group, (6) a carboxyl group, (7) an amino group, (8) a formyl group or (9) a group represented by the formula:

wherein X 1 and X 2 each independently represent a single bond, —CO—, —SO 2 — or C 1 -C 6 -methylene group; X 3 represents a single bond, —CO—, —SO 2 , —O—, —CO—O— or —O—CO—; R 3b represents a C 1 -C 6 alkylene group or a single bond; R 3a and R 3c represent a hydrogen atom, a C 1 -C 6 alkyl group which may be substituted, a C 2 -C 6 alkenyl group which may be substituted, a C 2 -C 6 alkynyl group which may be substituted, a C 3 -C 8 cycloalkyl group which may be substituted, a C 6 -C 14 aromatic cyclic hydrocarbon group which may be substituted, a 5- to 14-membered aromatic heterocyclic group which may be substituted or a hydrogen atom, provided that 6,7-dihydrobenzo[1,2]cyclohepta[3,4,5-cd]indazole is excluded.

2. A compound represented by the following formula, a salt thereof or a hydrate of them:

wherein Z 2 represents a 1,2-ethylene group which may be substituted, a 1,2-vinylene group which may be substituted, an oxymethylene group which may be substituted, an aminomethylene group which may be substituted, an amide group which may be substituted or an ester group; and the ring A, R 1a , R 2a , R 2b and R 2c have the same meanings as the ring A, R 1a , R 2a , R 2b and R 2c described in claim 1 , provided that 6,7-dihydrobenzo[1,2]cyclohepta[3,4,5-cd]indazole is excluded.

3. A compound represented by the following formula, a salt thereof or a hydrate of them

wherein R 1a , R 2a , R 2b and R 2c have the same meanings as R 1a , R 2a , R 2b and R 2c described in claim 1 , respectively; Z 2 represents a 1,2-ethylene group which may be substituted, a 1,2-vinylene group which may be substituted, an oxymethylene group which may be substituted, an aminomethylene group which may be substituted, an amide group which may be substituted, or an ester group; and R 2d , R 2e , R 2f , R 2g , R 2h and R 2i each independently represent a substituent selected from the Substituent Group (a) described in claim 1 .

4. A compound represented by the following formula, a salt thereof or a hydrate of them:

wherein R 1a , R 2a , R 2b and R 2c have the same meanings as R 1a , R 2a , R 2b and R 2c described in claim 1 , respectively; Z 2 represents a 1,2-ethylene group which may be substituted, a 1,2-vinylene group which may be substituted, an oxymethylene group which may be substituted, an aminomethylene group which may be substituted, an amide group which may be substituted, or an ester group; R 2d , R 2e , R 2f and R 2g each independently represent a substituent selected from the Substituent Group (a) described in claim 1 ; and Z 3 represents a nitrogen atom, an oxygen atom, a sulfur atom or a group represented by the formula —NR 4b — wherein R 4b represents a hydrogen atom or a C 1 -C 6 alkyl group.

5. A compound represented by the following formula, a salt thereof or a hydrate of them:

wherein R 1a , R 2a , R 2b and R 2c have the same meanings as R 1a , R 2a , R 2b and R 2c described in claim 1 , respectively; Z 2 represents a 1,2-ethylene group which may be substituted, a 1,2-vinylene group which may be substituted, an oxymethylene group which may be substituted, an aminomethylene group which may be substituted, an amide group which may be substituted, or an ester group; R 2d , R 2e , R 2f and R 2g each independently represent a substituent selected from the Substituent Group (a) described in claim 1 ; and Z 3 represents a nitrogen atom, an oxygen atom, a sulfur atom or a group represented by the formula —NR 4b — wherein R 4b repesents a hydrogen atom or a C 1 -C 6 group.

6. A compound represented by the following formula, a salt thereof or a hydrate of them:

wherein R 1a , R 2a , R 2b and R 2c have the same meanings as R 1a , R 2a , R 2b and R 2c described in claim 1 , respectively; Z 2 represents a 1,2-ethylene group which may be substituted, a 1,2-vinylene group which may be substituted, an oxymethylene group which may be substituted, an aminomethylene group which may be substituted, an amide group which may be substituted, or an ester group; and R 2d , R 2e , R 2f and R 2g each independently represent a substituent selected from the Substituent Group (a) described in claim 1 , provided that 6,7-dihydrobenzo[1,2]cyclohepta[3,4,5-cd]indazole is excluded.

7. The compound according to any one of claims 3 to 6 , a salt thereof or a hydrate of them, wherein at least five of R 2a , R 2b , R 2c , R 2d , R 2e , R 2f and R 2g are hydrogen atoms.

8. The compound according to claim 2 , a salt thereof or a hydrate of them, wherein Z 2 is a 1,2-ethylene group, a 1,2-vinylene group, a group represented by the formula —CO—NR 4a — wherein R 4a represents a hydrogen atom or a C 1 -C 6 alkyl group or a group represented by the formula —NR 4a —CO— wherein R 4a represents a hydrogen atom or a C 1 -C 6 alkyl group.

9. The compound according to claim 1 or 2 , a salt thereof or a hydrate of them, wherein the ring A is a benzene ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , a naphthalene ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , an indole ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , a benzofuran ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , a benzothiophene ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , a pyridine ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , a furan ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 , or a thiophene ring which may have one to three groups selected from the Substituent Group (a) described in claim 1 .

10. The compound according to claim 1 or 2 , a salt thereof or a hydrate of them, wherein the ring A is a ring having one group selected from the Substituent Group (a) described in claim 1 .

11. The compound according to claim 1 , a salt thereof or a hydrate of them, wherein R 1a is a hydrogen atom.

12. The compound according to claim 1 , a salt thereof or a hydrate of them, wherein R 2a and R 2b are hydrogen atoms.

13. A c-Jun amino-terminal kinase (JNK) inhibitor, comprising the compound according to claim 1 , a salt thereof or a hydrate of them.

14. A c-Jun amino-terminal kinase 1 (JNK 1), c-Jun amino-terminal kinase 2 (JNK 2) and/or c-Jun amino-terminal kinase 3 (JNK 3) inhibitor, comprising the compound according to claim 1 , a salt thereof or a hydrate of them.