Core-shell magnetic nanoparticles comprising an inner-transition element
Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as Fe x M a v Z y and a shell of an inner-transition element M b or the compound thereof, wherein M a is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.
1. A magnetic nanoparticle comprising:
a core represented as Fe x M a v Z y , wherein M a is an inner-transition element, Z is oxygen, x is greater or equal to 0, and v, y are positive numbers; and
a shell of an inner-transition element M b or the compound thereof.
2. The magnetic nanoparticle as claimed in claim 1 , wherein the inner-transition elements M a and M b are selected from the lanthaniides or the actinides.
3. The magnetic nanoparticle as claimed in claim 1 , wherein the inner-transition elements M a and M b are the same element.
4. The magnetic nanoparticle as claimed in claim 1 , wherein the inner-transition elements M a and M b are different elements.
5. The magnetic nanoparticle as claimed in claim 1 , wherein the compound of the inner-transition element M b is a complex.
6. The magnetic nanoparticle as claimed in claim 1 , wherein the magnetic nanoparticle is applicable in imaging, diagnosis, therapy and biomaterial separation.
7. The magnetic nanoparticle as claimed in claim 1 , further modified by at least one molecule.
8. The magnetic nanoparticle as claimed in claim 7 , wherein the molecule is a liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.
9. The magnetic nanoparticle as claimed in claim 7 , wherein the magnetic nanoparticle further reacts with at least one substance having specificity.
10. The magnetic nanoparticle as claimed in claim 9 , wherein the substance having specificity is an antibody, a protein, a peptide, an enzyme, a carbohydrate, a glycoprotein, a nucleotide or a lipid.
11. The magnetic nanoparticle as claimed in claim 1 , wherein the magnetic nanoparticle further reacts with at least one substance having specificity.
12. The magnetic nanoparticle as claimed in claim 11 , wherein the substance having specificity is an antibody, a protein, a peptide, an enzyme, a carbohydrate, a glycoprotein, a nucleotide or a lipid.
13. The magnetic nanoparticle as claimed in claim 1 , further comprising a coupling agent between the core and the shell.
14. The magnetic nanoparticle as claimed in claim 13 , wherein the coupling agent has terminal functional groups comprising carboxyl group or amino group.
15. A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation, comprising:
a core represented as Fe x M a v Z y , wherein Ma is an inner-transition element, Z is oxygen, x is greater or equal to 0, and v, y are positive numbers; and
a shell of an inner-transition element Mb or the compound thereof.
16. The magnetic nanoparticle as claimed in claim 15 , wherein the inner-transition elements M a and M b are selected from the lanthanides or the actinides.
17. The magnetic nanoparticle as claimed in claim 15 , wherein the inner-transition elements M a and M b are the same element.
18. The magnetic nanoparticle as claimed in claim 15 , wherein the inner-transition elements M a and M b are different elements.
19. The magnetic nanoparticle as claimed in claim 15 , wherein the compound of the inner-transition element M b is a complex.
20. The magnetic nanoparticle as claimed in claim 15 , further modified by at least one molecule.
21. The magnetic nanoparticle as claimed in claim 20 , wherein the molecule is a liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.
22. The magnetic nanoparticle as claimed in claim 20 , wherein the magnetic nanoparticle further reacts with at least one substance having specificity.
23. The magnetic nanoparticle as claimed in claim 22 , wherein the substance having specificity is an antibody, a protein, a peptide, an enzyme, a carbohydrate, a glycoprotein, a nucleotide or a lipid.
24. The magnetic nanoparticle as claimed in claim 15 , wherein the magnetic nanoparticle further reacts with at least one substance having specificity.
25. The magnetic nanoparticle as claimed in claim 24 , wherein the substance having specificity is an antibody, a protein, a peptide, an enzyme, a carbohydrate, a glycoprotein, a nucleotide or a lipid.
26. The magnetic nanoparticle as claimed in claim 15 , further comprising a coupling agent between the core and the shell.
27. The magnetic nanoparticle as claimed in claim 26 , wherein the coupling agent has terminal functional groups comprising carboxyl group or amino group.