Closed-loop method for controlling insulin infusion
A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin.
1. A method of infusing a fluid into a body of a user, the method comprising:
obtaining a current blood glucose concentration of the user;
generating a controller input based on the current blood glucose concentration;
generating commands by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain, wherein a proportional component and a derivative component of the PID controller are combined to represent a first phase insulin response, as measured from a normal glucose tolerant individual, and an integral component of the PID controller represents a second phase insulin response, as represented by the steady increase in insulin release under hyperglycemic clamp; and
infusing the fluid based on the commands from the PID controller;
wherein the PID controller accurately estimates a hypoglycemic glucose excursion.
2. The method of infusing a fluid into a body of a user in accordance with claim 1 , wherein the PID controller is a bilinear PID controller.
3. A system for infusing a fluid into a body of a user, the system comprising:
means for obtaining a current blood glucose concentration of the user;
means for generating a controller input based on the current blood glucose concentration;
means for generating commands by a proportional plus, integral plus, derivative (PID) controller from the controller input using at least one preset controller gain, wherein a proportional component and a derivative component of the PID controller are combined to represent a first phase insulin response, as measured from a normal glucose tolerant individual, and an integral component of the PID controller represents a second phase insulin response, as represented by the steady increase in insulin release under hyperglycemic clamp; and
means for infusing the fluid based on the commands from the PID controller;
wherein the PID controller accurately estimates a hypoglycemic glucose excursion.
4. The system for infusing a fluid into a body of a user in accordance with claim 3 , wherein the PID controller is a bilinear PID controller.