Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R 1 , R′ 1 , R 2 , R′ 2 , R 3 , R′ 3 , R 4 , R′ 4 , R 5 , R′ 5 , R 6 , R′ 6 , R 7 , R′ 7 , R 8 , R′ 8 , R 9 , R′ 9 , M, X, Y, Z and n are defined herein for use as contrast agents in diagnostic imaging.
1. A compound which is complex represented by the
wherein said biomolecule is independently selected from the group consisting of steroids, carbohydrates, fatty acids, amino acids, peptides, proteins, antibodies, vitamins, lipids, phospholipds, phosphates, phosphonates, nucleic acids, enzyme substrates, enzyme inhibitors and enzyme receptor substrates.
2. Compound of claim 1 wherein the biomolecule is a carbohydrate.
3. Compound of claim 2 wherein the biomolecule is a polysaccharide.
4. Compound of claim 3 wherein the biomolecule is a glycosaminoglycan.
5. Compound of claim 3 wherein the biomolecule is hyaluronic acid.