Warming and nonirritating lubricant compositions and method of comparing irritation

1. A substantially anhydrous lubricant composition comprising at least one polyhydric alcohol, which increases in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg and wherein said polyhydric alcohol is selected from the group consisting of: glycerin, alkylene glycol, polyethylene glycol, PEGylated compounds, block copolymers comprising polyalkylene glycol and a mixture thereof and wherein said polyethylene glycol is selected from the group consisting of polyethylene glycol 300, polyethylene glycol 400 and a mixture thereof and further comprising an insulating agent having high bulk properties selected from the group consisting of honey, isopropyl myristate and isopropyl palmitate.

2. A composition according to claim 1 wherein said composition further comprises a local anesthetic.

3. A substantially anhydrous lubricant composition comprising from about 80% to about 98% by weight polyhydric alcohol and from about 1 to about 5% by weight insulating agent selected from the group consisting of honey, isopropyl myristate and isopropyl palmitate and less than about 5% by weight water.

4. A composition according to claim 3 wherein said composition comprises from about 80% to about 98% by weight polyhydric alcohol and from about 1 to about 5% by weight insulating agent selected from the group consisting of honey, isopropyl myristate and isopropyl palmitate and less than about 1% by weight water.

5. A method of treating vulvodynia comprising applying a composition comprising at least one polyol and an analgesic agent, which increases in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg to a skin or mucosal surface.

6. A method of treating frostbite comprising applying a composition comprising at least one polyol, which increases in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg to skin on a frostbitten extremity.

7. A method of treating dysmenorrhea comprising applying a composition comprising at least one polyol and an anti-inflammatory agent, which increases in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg to a tampon and inserting said tampon vaginally.

8. A substantially anhydrous lubricant composition consisting essentially of at least one polyol, which increases in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg wherein said composition further comprises a bioadhesive agent.

9. A substantially anhydrous lubricant composition comprising at least one polyhydric alcohol, which increases in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg and wherein said polyhydric alcohol is selected from the group consisting of: glycerin, alkylene glycol, polyethylene glycol, PEGylated compounds, block copolymers comprising polyalkylene glycol and a mixture thereof and wherein said polyethylene glycol is selected from the group consisting of polyethylene glycol 300, polyethylene glycol 400 and a mixture thereof, said composition further comprising an insulating agent having high bulk properties selected from the group consisting of honey, isopropyl myristate and isopropyl palmitate.

10. A composition according to claim 9 wherein said composition further comprises a local anesthetic.

11. A substantially anhydrous lubricant composition consisting essentially of at least one polyol and a bioadhesive agent said composition increasing in temperature by at least about 5° C. upon exposure to moisture and which has an Energy Release Index of at least about 11 mJ/mg.