Antibody composition-producing cell
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
1. An isolated mammalian host cell which has decreased or no α1,6-fucosyltransferase activity for adding fucose to N-acetylglucosamine of a reducing terminus of N-glycoside-linked sugar chains by deleting a gene encoding α1,6-fucosyltransferase or by adding a mutation to said gene to reduce or eliminate the α1,6-fucosyltranferase activity, wherein said mammalian host cell produces an antibody molecule.
2. The isolated host cell of claim 1 , wherein said host cell is a CHO cell.
3. The isolated host cell of claim 1 , wherein said host cell is a NS0 cell.
4. The isolated host cell of claim 1 , wherein said host cell is a SP2/0 cell.
5. The isolated host cell of claim 1 , wherein said host cell is a YB2/0 cell.
6. The isolated host cell of claim 1 wherein said antibody molecule is an IgG antibody.