Granted Patent
B2
US 7,462,641 · App. 10/565,294 · Granted Dec 9, 2008
(2S,4S)-4-fluoro-1-[4-fluoro-beta-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile
Assignee:
SmithKline Beecham Corporation
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Abstract
The present invention includes anhydrous crystalline forms of (2S,4S)-4-fluoro-1-[4-fluoro-β-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt.
Claims (16)
1. A crystalline form of anhydrous form 1 of (2S,4S)-4-fluoro-1-[4-fluoro-β-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt characterized by a powder x-ray diffraction pattern comprising at least one of the following peaks:
d-spacing
Two theta (deg)*
(angstroms)
6.1 ± 0.2
14.4 ± 0.5
6.4 ± 0.2
13.9 ± 0.5
7.7 ± 0.2
11.5 ± 0.3
22.2 ± 0.2
4.0 ± 0.1
24.7 ± 0.2
3.6 ± 0.1
*Using copper K-alpha 1 radiation.
2. The crystalline form of claim 1 comprising two or more of the following peaks:
Continuity (2)
Provisional Application
6048890200
· Jul 21, 2003