Granted Patent
B2
US 7,485,283 · App. 11/113,486 · Granted Feb 3, 2009
Contrast agents for myocardial perfusion imaging
Assignee:
Lantheus Medical Imaging
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Abstract
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.
Claims (12)
1. A contrast agent of formula (IV)
wherein
n, m, and o are independently 1, 2, 3, or 4;
Z is O, S, or NR 46 ;
R 45 is an imaging moiety or C 1 -C 4 alkyl optionally substituted with an imaging moiety;
R 45 is hydrogen or C 1 -C 3 alkyl;
Ar is phenyl, furyl, thienyl, oxazolinyl, isoxazolinyl, thiazolyl, isothiazolyl, pyridyl, naphthyl, pyrimidinyl, or pyrazinyl;
G is absent or O; and
L is an imaging moiety;
provided that when G is absent, o is 3.
2. A contrast agent which is
3. A contrast agent which is
Assignments (20)
RELEASE OF SECURITY INTEREST
Recorded Dec 2, 2022
From: WELLS FARGO BANK, N.A.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 062047/0925 →
SECURITY INTEREST
Recorded Dec 2, 2022
From: LANTHEUS MEDICAL IMAGING, INC.; MOLECULAR INSIGHT PHARMACEUTICALS, INC.; PSMA DEVELOPMENT COMPANY, LLC; PROGENICS PHARMACEUTICALS, INC.
To: CITIZENS BANK, N.A.
Reel/Frame 062047/0960 →
SECURITY AGREEMENT
Recorded Jun 28, 2019
From: LANTHEUS MEDICAL IMAGING, INC.
To: WELLS FARGO BANK, N.A.
Reel/Frame 049628/0001 →
RELEASE OF SECURITY INTEREST
Recorded Jun 27, 2019
From: JPMORGAN CHASE BANK, N.A.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 049623/0123 →
RELEASE OF SECURITY INTEREST IN CERTAIN PATENTS
Recorded Mar 30, 2017
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: LANTHEUS HOLDINGS, INC.; LANTHEUS MEDICAL IMAGING, INC.; LANTHEUS MI REAL ESTATE, LLC
Reel/Frame 042115/0715 →
NOTICE OF SUCCESSION OF AGENCY
Recorded Mar 30, 2017
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 042115/0769 →
SECURITY AGREEMENT
Recorded Jun 30, 2015
From: LANTHEUS MEDICAL IMAGING, INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 036013/0516 →
ASSIGNMENT OF SECURITY INTEREST IN PATENTS
Recorded Jul 3, 2013
From: BMO HARRIS BANK N.A.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ASSIGNEE
Reel/Frame 030740/0335 →
RELEASE OF PATENT SECURITY AGREEMENT
Recorded May 13, 2010
From: ABLECO FINANCE LLC
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 024380/0363 →
SECURITY AGREEMENT
Recorded May 13, 2010
From: LANTHEUS MEDICAL IMAGING, INC.
To: HARRIS N.A., AS COLLATERAL AGENT
Reel/Frame 024390/0733 →
CHANGE OF NAME
Recorded Jan 30, 2009
From: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 022184/0696 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 28, 2009
From: RADEKE, HEIKE S; CASEBIER, DAVID S; AZURE, MICHAEL T; DISCHINO, DOUGLAS D
To: BRISTOL-MYERS SQUIBB PHARMA COMPANY
Reel/Frame 022167/0251 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 28, 2009
From: BRISTOL-MYERS SQUIBB PHARMA COMPANY
To: ACP LANTERN ACQUISITION, INC.
Reel/Frame 022168/0578 →
MERGER
Recorded Jan 28, 2009
From: ACP LANTERN ACQUISITION, INC.
To: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
Reel/Frame 022168/0893 →
CHANGE OF NAME
Recorded Mar 7, 2008
From: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 020609/0746 →
MERGER
Recorded Mar 7, 2008
From: ACP LANTERN ACQUISITION, INC.
To: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
Reel/Frame 020609/0733 →
GRANT OF SECURITY INTEREST
Recorded Mar 6, 2008
From: ACP LANTERN ACQUISITION, INC.
To: ABLECO FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 020609/0506 →
ASSIGNMENT OF PATENTS
Recorded Jan 9, 2008
From: BRISTOL-MYERS SQUIBB PHARMA COMPANY
To: ACP LANTERN ACQUISITION, INC.
Reel/Frame 020339/0341 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF ASSIGNEE (OUR ERROR ON RECORDATION SHEET) PREVIOUSLY RECORDED ON REEL 016549 FRAME 0262. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT ASSIGNEE IS BRISTOL-MYERS SQUIBB PHARMA COMPANY.
Recorded Sep 20, 2005
From: RADEKE, HEIKE S.; CASEBIER, DAVID S.; DISCHINO, DOUGLAS D.; AZURE, MICHAEL T.
To: BRISTOL-MYERS SQUIBB PHARMA COMPANY
Reel/Frame 016557/0619 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 21, 2005
From: RADEKE, HEIKE S.; CASEBIER, DAVID S.; AZURE, MICHAEL T.; DISCHINO, DOUGLAS D.
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 016549/0262 →
Continuity (2)
Provisional Application
6056614600
· Apr 28, 2004