Treatment with anti-ErbB2 antibodies and anti-hormonal compounds
The present application describes methods for treating cancer with anti-ErbB2 antibodies, such as humanized anti-ErbB2 antibodies, and anti-hormonal compounds, such as anti-estrogens.
1. A method of treating ErbB2-expressing cancer in a human, comprising administering to the human therapeutically effective amounts of (a) an antibody which binds ErbB2 and comprises the variable light (V L ) domain amino acid sequence of SEQ ID NO: 3 and the variable (V H ) domain amino acid sequence of SEQ ID NO: 4; and (b) an anti-estrogen compound that regulates or inhibits estrogen action on tumors.
2. The method of claim 1 wherein the antibody blocks ligand activation of an ErbB receptor.
3. The method of claim 1 wherein the cancer is not characterized by overexpression of ErbB2 receptor.
4. The method of claim 1 wherein the cancer is breast cancer.
5. The method of claim 4 wherein the cancer is metastatic breast cancer.
6. The method of claim 1 wherein the antibody is an intact IgG1 antibody.
7. The method of claim 1 wherein the antibody and anti-estrogen compound are coadministered, using separate formulations or a single formulation.
8. The method of claim 1 wherein the antibody and anti-estrogen compound are consecutively administered in either order.
9. The method of claim 8 wherein there is a time period during which both the antibody and the anti-estrogen compound simultaneously exert their biological activities.
10. A method of treating cancer in a human, wherein the cancer expresses but does not overexpress ErbB2 receptor, comprising administering to the human therapeutically effective amounts of (a) an antibody which binds to ErbB2 and blocks ligand activation of an ErbB receptor more effectively than humanized monoclonal antibody huMAb4D5-8; and (b) an anti-estrogen compound that regulates or inhibits estrogen action on tumors.
11. The method of claim 10 wherein the cancer is breast cancer.
12. The method of claim 11 wherein the cancer is metastatic breast cancer.
13. The method of claim 11 further comprising administering a chemotherapeutic agent to the human.
14. A method of treating breast cancer in a human, wherein the breast cancer expresses but does not overexpress ErbB2 receptor, comprising administering to the human therapeutically effective amounts of (a) an antibody which binds ErbB2 and blocks by 50% or greater binding of monoclonal antibody 2C4 (ATCC HB-12697) to ErbB2; and (b) an anti-estrogen compound that regulates or inhibits estrogen action on tumors.