Compositions and methods for the diagnosis and treatment of tumor
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
1. An isolated antibody which binds specifically to the polypeptide of SEQ ID NO:3.
2. The antibody of claim 1 which is a monoclonal antibody.
3. The antibody of claim 1 which is an antibody fragment that binds specifically to the polypeptide of SEQ ID NO: 3.
4. The antibody of claim 1 which is a chimeric or a humanized antibody.
5. The antibody of claim 1 which is conjugated to a growth inhibitory agent.
6. The antibody of claim 1 which is conjugated to a cytotoxic agent.
7. The antibody of claim 6 , wherein the cytotoxic agent is selected from the group consisting of toxins, antibodies, radioactive isotopes and nucleolytic enzymes.
8. The antibody of claim 6 , wherein the cytotoxic agent is a toxin.
9. The antibody of claim 8 , wherein the toxin is selected from the group consisting of maytansinoid and calicheamicin.
10. The antibody of claim 8 , wherein the toxin is a maytansinoid.
11. The antibody of claim 1 which is produced in bacteria.
12. The antibody of claim 1 which is produced in CHO cells.
13. The antibody of claim 1 which induces death of a cell to which it binds.
14. The antibody of claim 1 which is detectably labeled.