Vanilloid receptor modulators
Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 , R 2 , R 3 , P, X, Y, q, r ans s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.
1. A compound of formula (IB),
or a pharmaceutically acceptable salt thereof,
wherein, P is selected from the group consisting of phenyl, pyridyl, piperidinyl, piperazinyl, and morpholinyl;
R 1 is CH 3 ;
R 2 is Cl;
each R 3 is independently selected from the group consisting of alkyl; alkoxy; —CF 3 ; halo—O(CH 2 ) OR 6 ; —O(CH 2 ) NR 4 R 5 ; phenyl optionally substituted with one or more C 1 -C 6 -alkyl, trifluoromethyl, methoxy, acetyl, halo, or CH 3 ) 2 NS(O) 2 -groups cyclohexyl;
benzo[1,3]dioxolyl; morpholinyl pyridyl optionally substituted with one or more chloro or methyl groups; piperazinyl optionally substituted with a methoxycarbonyl group; piperidinyl; thienyl; furyl; pyrazolyl; indanyl; oxazolyl; methylthiazolyl; oxadiazolyl; isothiazolyl; isoxazolyl; and thiadiazolyl;
R 4 and R 5 are each methyl;
R 6 is methyl;
X is N and Y is CR 9 ; or X is CR 9 and Y is N;
R 9 is H or R 1 ;
n is an integer value from 1 to 6;
q is 0 or 1;
r is 0 or 1, and
s is 0, 1, 2 or 3.
2. A pharmaceutical composition, which comprises the compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient therefor.
3. The compound of claim 1 which is represented by the following formula:
or a pharmaceutically acceptable salt thereof; wherein
P is phenyl or pyridyl;
Y is CH and X is N; or Y is N and X is CH;
each R 3 is independently; —CF 3 ; methyl; fluoro; chloro; bromo; morpholinyl; piperidinyl;
thienyl; pyrazolyl; methylthiazolyl; phenyl optionally substituted with one or more substituents selected from the group consisting of methyl, trifluoromethyl, methoxy, and chloro; or pyridyl optionally substituted with methyl or chloro;
q is 0;
r is 0; and
s is 1, 2, or 3.
4. The compound of claim 3 which is represented by the following structure:
or a pharmaceutically acceptable salt thereof; wherein
P is phenyl;
Y is CH; and
X is N.
5. The compound of claim 3 or a pharmaceutically acceptable salt thereof wherein:
P is pyridyl;
Y is CH; and
X is N.
6. The compound of claim 1 or a pharmaceutically acceptable salt thereof which is represented by the following formula:
7. The compound of claim 1 or a pharmaceutically acceptable salt thereof which is represented by the following formula: