Acylated piperidine derivatives as melanocortin 4-receptor agonists
Certain novel N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 which is:
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 which is:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition which comprises a compound of claim 1 and a pharmaceutically acceptable carrier.
5. The compound of claim 1 wherein the pharmaceutically acceptable salt is the hydrochloride salt.
6. A compound selected from the group consisting of:
r
R10
R5
R7
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
CF 3
1
F
1
F
1
F
1
F
1
Cl
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
1
F
or a pharmaceutically acceptable salt thereof.