Devices and methods for collection, storage and transportation of biological specimens

1. A device for collecting, storing or transporting a biological specimen, said device comprising:

(a) a container defining an interior space having side walls, a bottom and an openable and sealable lid having an internal surface lid extension for mounting an absorbent matrix thereon;

(b) a solid three-dimensional matrix removably mounted on the lid extension inside the container, wherein the matrix is at least 20% porous and is configured to absorb a volume of at least 0.1 ml of a liquid suspension comprising a liquid and a biological specimen, and wherein the matrix is configured for subsequent drying and then storing the dried biological specimen thereon inside the container,

(c) a desiccant inside the container separated from the matrix by an air permeable barrier and in vaporous communication with said matrix, wherein the desiccant is present in an excess amount to maintain dry conditions for the volume of biological specimen present in the matrix so as to prohibit enzymatic and cellular biological activity in the biological specimen,

(d) a colorimetric indicator of moisture within the desiccant; and

(e) the dried biological specimen in the matrix, inactive with respect to enzymatic and cellular biological activity.

2. The device of claim 1 , wherein the matrix is configured to absorb at least 0.5 ml of the liquid suspension comprising the biological specimen.

3. The device of claim 1 , wherein the matrix is configured to absorb 1.0 ml of the liquid suspension comprising the biological specimen.

4. The device of claim 1 , wherein the matrix is at least 50% porous.

5. The device of claim 1 . wherein the matrix is at least 90% porous.

6. The device of claim 1 , wherein said matrix is three-dimensional in a shape selected from the group consisting of a cylinder, cube, sphere, pyramid. and cone.

7. The device of claim 1 , wherein said matrix is in the shape of a cylinder about 20 mm in length and 8 mm in diameter.

8. The device of claim 1 , wherein said matrix comprises an absorbent material selected from the group consisting of cellulose acetate fibers, cellulose, nitrocellulose, carboxymethylcellulose, hydrophilic polymers, polypropylene, polyester, polyamide, carbohydrate polymers, polytetrafluroethylene, cotton, fiberglass and combinations thereof

9. The device of claim 1 , wherein said biological specimen contains an analyte of interest selected from the group consisting of nucleic acids, proteins, carbohydrates, lipids, whole cells, cellular fragments, whole virus and viral fragments,

10. The device of claim 1 , wherein said biological specimen contains an analyte of interest selected from the group consisting of DNA and RNA.

11. The device of claim 1 , wherein said biological specimen is selected from the group consisting of whole blood, plasma, serum, lymph, synovial fluid, urine, saliva, sputum, semen, vaginal lavage, bone marrow cerebrospinal cord fluid, physiological body liquids, pathological body liquids, and combinations thereof.

12. The device of claim 1 , wherein said liquid suspension comprising said biological specimen further comprises cell suspensions, liquid extracts, tissue homogenates, media from DNA or RNA synthesis, saline and combinations thereof.

13. The device of claim 1 , wherein said desiccant is selected from the group consisting of montmorillonite clay, lithium chloride, activated alumina, alkali alumino-silicate, silica gel, molecular sieve, calcium sulfate, and calcium oxide.

14. A kit for recovering a dried biological specimen, said kit comprising:

(a) the device,

(b) a reconstitution buffer,

(c) a compression device comprising a plunger within a barrel, and

(d) protocols for preparation and recovery of a dried biological specimen with the device of any of claims 1 - 8 and 9 - 13 , a controlled amount of the reconstitution buffer to reconstitute the biological sample to the former volume of the liquid suspension, and the compression device.