Antibacterial agents

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:

wherein:

Z 1 , Z 3 , and Z 4 are each independently N or CR 1a ;

Z 2 , Z 5 and Z 6 are each CR 1a ;

R 1 and R 1a are independently at each occurrence hydrogen; cyano; halogen; hydroxy; (C 1-6 )alkoxy unsubstituted or substituted by (C 1-6 )alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstitued or N-substituted by one or two (C 1-6 )alkyl, acyl, (C 1-6 )alkylsulphonyl, CONH 2 , hydroxy, (C 1-6 )alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C 1-6 )alkylsulphonyloxy; (C 1-6 )alkyl; (C 1-6 )alkylthio; trifluoromethyl; trifluoromethoxy; nitro; azido; acyl; acyloxy; acylthio; (C 1-6 )alkylsulphonyl; (C 1-6 )alkylsulphoxide; arylsulphonyl; arylsulphoxide; or an amino, piperidyl, guanidino or amidino group unsubstituted or N-substituted by one or two (C 1-6 )alkyl, acyl or (C 1-6 )alkylsulphonyl groups;

or R 1 and R 1a of Z 2 , or R 1 and R 1a of Z 1 together form ethylenedioxy;

A is CR 2 R 3 ;

R 2 is hydrogen; halogen; hydroxy; acyloxy; or (C 1-6 )alkoxy; and R 3 is hydrogen;

W 1 is CR 4 R 5 ;

R 4 is hydrogen; halogen; hydroxy; (C 1-6 )alkyl; (C 1-6 )hydroxyalkyl; C(═O)—NR 1d R 1d′ ; (C 1-6 )alkoxy; NR 1b R 1b′ or acyloxy; and R 5 is hydrogen or (C 1-6 )alkyl;

or R 4 and R 5 together are ═N—OH;

R 1b and R 1b′ are each independently hydrogen; (C 1-6 )alkyl; aryl; heteroaryl; or together with the nitrogen to which they are attached form an aziridine, azetidine, pyrrolidine, piperidine or hexamethyleneimine ring (wherein said aziridine, azetidine, pyrrolidine, piperidine or hexamethyleneimine ring is optionally substituted with 1 to 3 substitutents selected from halogen, (C 1-6 )alkyl, hydroxy and aryl);

R 1d and R 1d′ are each independently hydrogen or (C 1-6 )alkyl;

W 2 is CR 6 ;

R 6 is hydrogen; halogen; hydroxy; (C 1-6 )alkyl; NR 1c R 1c′ ; acyloxy; or (C 1-6 )alkoxy;

R 1c and R 1c′ are each independently hydrogen; (C 1-6 )alkyl; aryl; heteroaryl; or together with nitrogen to which they are attached form an aziridine, azetidine, pyrrolidine, piperidine or hexamethyleneimine ring (wherein said azidirine, azetidine, pyrrolidine, piperidine or hexamethyleneimine ring is optionally substituted with 1 to 3 substituents selected from halogen, (C 1-6 )alkyl, hydroxy and aryl);

B is CR 7 R 8 or a bond;

R 7 and R 8 are each independently hydrogen or (C 1-6 )alkyl;

R 9 is hydrogen; aryl; heteroaryl; (C 1-6 )alkyl unsubstituted or substituted by one or two (C 1-6 )alkoxy, acyloxy, carboxy, hydroxy, amino, piperidyl, piperazinyl, morpholino, guanidino, or amidino, any of which is unsubstituted or N-substituted by one or two aryl, heteroaryl, halogen, unsubstituted (C 1-6 )alkyl, acyl, (C 1-6 )alkylsulphonyl, arylsulphonyl, hydroxy, (C 1-6 )alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy, or (C 1-6 )alkylsulphonyloxy; (C 1-6 )alkylcarbonyl; or (C 2-6 )alkenylcarbonyl;

R 10 is a group —U—R 11 where:

R 11 is:

R 12 , R 14 and R 15 are at each occurrence independently selected from: H; (C 1-4 )alkylthio; halo; (C 1-4 )alkyl; (C 2-4 )alkenyl; hydroxy; hydroxy(C 1-4 )alkyl; mercapto(C 1-4 )alkyl; (C 1-4 )alkoxy; trifluoromethoxy; nitro; cyano; carboxy; and amino or aminocarbonyl unsubstituted or substituted by (C 1-4 )alkyl;

R 13 is at each occurrence independently hydrogen; trifluoromethyl; (C 1-4 )alkyl unsubstituted or substituted by hydroxy, carboxy, (C 1-4 )alkoxy, (C 1-6 )alkylthio, halo or trifluoromethyl; (C 2-4 )alkenyl; or aminocarbonyl wherein the amino group is optionally substituted with (C 1-4 )alkyl;

U is C(═O); SO 2 ; or CR 16 R 17 ; and

R 16 and R 17 are independently selected from H; aryl; heteroaryl; (C 1-6 )alkyl; (C 1-6 )alkyl substituted by (C 1-6 )alkoxy, hydroxy, amino, piperidyl, piperazinyl, morpholino, guanidino, or amidino, any of which is substituted or N-substituted by one or two H, aryl, heteroaryl, halogen, cyano, CF 3 , (C 1-6 )alkyl, acyl, (C 1-6 )alkylsulphonyl, arylsulphonyl, hydroxy, (C 1-6 )alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy, or (C 1-6 )alkylsulphonyloxy; (C 1-6 )alkoxy-substituted (C 1-6 )alkyl; hydroxy-substituted(C 1-6 )alkyl; amino-substituted(C 1-6 )alkyl, which is N-substituted by one or two (C 1-6 )alkyl, acyl, (C 1-6 )alkylsulphonyl, or arylsulphonyl; (C 1-6 )alkylcarbonyl; (C 2-6 )alkenylcarbonyl; (C 1-6 )alkoxycarbonyl; CO 2 H; and CF 3 .

2. The compound according to claim 1 , wherein Z 1 and Z 4 are N and Z 3 is CR 1a .

3. The compound according to claim 1 , wherein R 1 is OCH 3 .

4. The compound according to claim 1 , wherein R 1a is at each occurrence independently hydrogen, halogen or cyano.

5. The compound according to claim 2 , wherein R 1a of Z 2 , Z 3 and Z 5 are each hydrogen; R 1a of Z 6 is hydrogen, halogen or cyano; and R 1 is OCH 3 .

6. The compound according to claim 1 , wherein R 2 is hydrogen or hydroxy.

7. The compound according to claim 1 , wherein B is CH 2 .

8. The compound according to claim 1 , wherein R 4 is hydroxyl and R 5 is hydrogen.

9. The compound according to claim 1 , wherein R 9 is hydrogen.

10. The compound according to claim 1 , wherein U is CH 2 .

11. The compound according to claim 1 , wherein R 11 is:

4H-Pyrido[3,2-b][1,4]thiazin-3-oxo-6-yl;

4H-Pyrido[3,2-b][1,4]oxazin-3-oxo-6-yl;

7-Chloro-4H-pyrido[3,2-b]oxazin-3-oxo-6-yl; or

7-Methyl-4H-pyrido[3,2-b][1,4]thiazin-3-oxo-6-yl.

12. The compound according to claim 1 , wherein the compound of formula (I) is:

a) 6-({[((3S)-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

b) 6-({[((3R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

f) 6-({[((3R)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

g) 6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

h) 6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

j) 7-chloro-6-({[((3R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

m) 6-(methyloxy)-4-{2-[(3S)-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-3-quinolinecarbonitrile;

o) 6-(methyloxy)-4-{2-[(3S)-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-3-quinolinecarbonitrile;

p) 6-(methyloxy)-4-{2-[(3S)-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-1,5-naphthyridine-3-carbonitrile;

s) 6-({[((3S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

t) 6-({[((3S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

v) 6-({[((3S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyt}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

w) 6-({[((3S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

y) 7-chloro-6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-y]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

z) 6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-y]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

aa) 6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ac) 6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-7-methyl-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ad) 6-({[((3S)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ae) 6-({[((3S)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)9methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

af) 6-({[((3R)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

ag) 6-({[((3R)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ah) 6-({[((3S)-1-{(2R)-2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-hydroxyethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ao) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ap) (±)-6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

aq) 6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ar) 6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

as) (±)-6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1 ,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

at) 6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

au) 6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

av) (±)-6-({[((cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

aw) 6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ax) 6-({[((3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ay) 6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

az) 6-({[((3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

ba) (±)-7-chloro-6-({[((cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

bb) 7-chloro-6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

bc) 7-chloro-6-({[((3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

bh) 6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bi) 6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

bj) (±)-6-({[((cis-3,4)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bk) 6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bl) (±)-6-({[((cis-3,4)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

bm) 6-({[((3S,4S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

bn) 6-({[((3S,4S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bp) (±)-6-[({[(cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(methyloxy)-3-pyrrolidinyl]methyl)amino}methyl]-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bq) (±)-6-[({[(cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(methyloxy)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

br) (±)-6-({[(3-fluoro-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bt) (±)-6-({[((3S,4R)-4-fluoro-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bu) (±)-6-({[((3S,4S)-4-fluoro-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bv) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-methyl-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bw) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-methyl-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bx) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-4-methyl-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

by) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-4-methyl-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

bz) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-methyl -3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ca) (±)-6-({[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-methyl -3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cd) (±)-4-{2-[3-methyl-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-6-(methyloxy)-3-quinolinecarbonitrile;

cf) 6-({[1-((3R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)-1-methylethyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ch) N-[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]lethyl}-3-pyrrolidinyl)methyl]-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxamide;

ci) N-[((3S)-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxamide;

cj) N-[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxamide;

ck) (±)-N-[((cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]-N-methyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxamide;

cl) (±)-N-[(1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]-N-methyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxamide;

cn) 6-({[((3S,4S)-1-{2-[8-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

co) 6-({[((3S,4S)-1-{2-[8-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cp) 6-({[((3S,4S)-1-{2-[6-fluoro-5-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cq) 6-({[((3S,4S)-1-{2-[6-fluoro-5-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

cr) 6-({[((3S,4S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cs) 6-({[((3S,4S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

ct) 6-{[({(3S,4S)-1-[2-(9-chloro-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-10-yl)ethyl]-4-hydroxy-3-pyrrolidinyl}methyl)amino]methyl}-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

cu) 6-{[({(3S,4S )-1-[2-(9-chloro-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-10-yl)ethyl]-4-hydroxy-3-pyrrolidinyl}methyl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cv) 6-{[({(3S,4S)-1-[2-(2,3-dihydro[1,4]dioxino[2,3-f]quinolin-10-yl)ethyl]-4-hydroxy-3-pyrrolidinyl}methyl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cw) 6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

cy) 7-chloro-6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

dc) 6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

dd) 6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

dg) N-[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carboxamide;

dh) (±)-6-[({[(3R,4S)/(3S,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(hydroxymethyl)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]thiazin -3(4H)-one;

di) (±)-6-[({[(3R,4S)/(3S,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(hydroxymethyl)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

dj) 6-[({[(3R,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(hydroxymethyl)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

dk) (±)-6-[({[(3S,4R)/(3S,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(hydroxymethyl)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

dm) 6-[({[(3R,4Z)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(hydroxyimino)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

dn) 6-[({[(3R,4Z)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-(hydroxyimino)-3-pyrrolidinyl]methyl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

dp) (±)-(3S,4S)/(3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-3-pyrrolidinecarboxamide;

dq) (±)-(3S,4S)/(3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}methyl)-3-pyrrolidinecarboxamide;

ds) 4-{2-[(3S,4S)-3-hydroxy-4-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-6-(methyloxy)-1,5-naphthyridine-3-carbonitrile;

dt) 4-{2-[(3S,4S)-3-hydroxy-4-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-6-(methyloxy)-1,5-naphthyridine-3-carbonitrile;

dv) (±)-6-{[((3S,4R)/(3R,4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)amino]methyl}-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one; or

dw) (±)-6-{[((3S,4R)/(3R,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)amino]methyl}-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one.

13. A pharmaceutical composition comprising the compound according to claim 1 and at least one pharmaceutically acceptable excipient.

14. The compound according to claim 1 , wherein:

Z 1 and Z 4 are N;

Z 3 is CR 1a ;

R 1 is OMe;

R 1a of Z 2 , Z 3 , and Z 5 are hydrogen;

R 1a of Z 6 is hydrogen, fluoro, chloro, or cyano;

R 2 is hydrogen or hydroxy;

R 4 is hydrogen, hydroxy, fluoro, methyl, or methoxy;

R 5 is hydrogen or methyl;

R 6 is hydrogen; hydroxy; fluoro; or methyl;

R 7 and R 8 are independently hydrogen or methyl;

R 9 is hydrogen or methyl; and

U is CH 2 ; SO 2 or C(═O).

15. The compound according to claim 14 , wherein R 11 is 4H-Pyrido[3,2-b][1,4]thiazin-3-oxo-6-yl, 4H-Pyrydo[3,2-b]oxazin-3-oxo-6-yl, 7-Chloro-4H-pyrido[3,2-b]oxaxin-3-6-yl, or 7-Methyl-4H-pyrido[3,2-b][1,4]thiazin-3-oxo-6-yl.

16. The compound according to claim 1 , wherein the compound of formula (I) is selected from:

6-({[((3S)-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3R)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrotidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

7-chloro-6-({[((3R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-(methyloxy)-4-{2-[(3S)-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b1][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-3-quinolinecarbonitrile;

6-(methyloxy)-4-{2-[(3S)-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-1,5-naphthyridine-3-carbonitrile;

6-(methyloxy)-4-{2-[(3S)-3-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-1,5-naphthyridine-3-carbonitrile;

6-({[((3S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

7-chloro-6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

-({[((3S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3R)-1-{(2S)-2-hydroxy-2-[6-methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3R)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3R)-1-{(2S)-2-hydroxy-2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S)-1-{(2R)-2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-hydroxyethyl}-3-pyrrolidinyl )methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

(±)-6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl )methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one (Enantiomer 1);

6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl )methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one (Enantiomer 2);

(±)-6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl )methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl )methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (Enantiomer 1);

6-({[(trans-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl )methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (Enantiomer 2);

(±)-6-({[((cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrotidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

(±)-7-chloro-6-({[((cis-3,4)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

7-chloro-6-({[((3S ,4S)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

7-chloro-6-({[((3R,4R)-1-{2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3-fluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

(±)-6-({[((cis-3,4)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]lethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

(±)-6-({[((cis-3,4)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrotidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3-chloro-6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[8-fluoro-6-(methyloxy)-4-quinoliny]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[8-fluoro-6(methyloxy)-4-quinoliny]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrroidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S,4S)-1-{2-[3,8-difluoro-6-(methyloxy)-4-quinolinyl]ethyl}-4-hydroxy-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

7-chloro-6-({[((3,S4S)-4-hydroxy-1-{2-[6-(methyloxy)-1,5-naphthyridin-4-yl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;

6-({[((3S,4S)-4-hydroxy-1-{2-[6-(methyloxy)-4-quinolinyl]ethyl}-3-pyrrolidinyl)methyl]amino}methyl)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;

4-{2-[(3S,4S)-3-hydroxy-4-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-6-(methyloxy)-1,5-naphthyridine-3-carbonitrile; and

4-{2-[(3S,4S)-3-hydroxy-4-({[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}methyl)-1-pyrrolidinyl]ethyl}-6-(methyloxy)-1,5-naphthyridine-3-carbonitrile.

17. A pharmaceutical composition comprising the compound according to claim 16 and at least one pharmaceutically acceptable excipient.