Adhesive laminates for rapid wound occlusion
View Patent ↗Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.
1. A laminate device for protecting an adhesive during manipulation thereof, comprising:
a continuous layer of an activatable protein adhesive; and
at least one layer of a biocompatible non-adherent and dissolvable substance disposed in protective and covering relationship on an outer surface of said adhesive layer.
2. The laminate device of claim 1 , wherein said adhesive is porous or permeable.
3. The laminate device of claim 1 , wherein one or more layers of said biocompatible non-adherent substance further comprises an emulsifying agent, a solubilizing agent, a wetting agent, a taste modifying agent, a plasticizer, a bioactive agent, a water soluble inert filler, a preservative, a buffering agent, a coloring agent, a stabilizer, or a combination thereof.
4. The laminate device of claim 1 , wherein said dissolvable substance is dissolvable in water.
5. The laminate device of claim 1 , wherein one or more layers of said biocompatible non-adherent substance comprises a hydrocolloid.
6. The laminate device of claim 5 , wherein said hydrocolloid is pullulan.
7. The laminate device of claim 1 , further comprising at least one removable layer disposed in contact with said adhesive.
8. The laminate device of claim 7 , wherein the removable layer is disposed in contact with said adhesive, said removable layer removable prior to manipulation of said adhesive.
9. The laminate device of claim 7 , wherein the removable layer is disposed between said adhesive and said biocompatible non-adherent substance or is disposed in covering relationship to an outer layer of said biocompatible non-adherent substance, said removable layer removable after manipulation of said adhesive.
10. The laminate device of claim 7 , wherein said removable layer comprises a polymer, Polytetrafluoroethylene (PTFE) or a cellulose impregnated with a lipid.
11. The laminate device of claim 10 , wherein said lipid is a lecithin, polyethylene glycol or a wax.