Topical formulations and methods of use
A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-1-carnitine, and 1-carnosine.
1. A method of treating skin, said method comprising administering a topical composition comprising:
(a) 5.0% R-lipoic acid,
2.0% acetyl-1-carnitine,
1.0% carnosine,
1.0% astaxanthin,
0.5% tocotrienol,
0.5% tocopherol,
1.0% sesame oil,
0.5% grape proanthocyanidin, and
0.05% E.D.T.A. (ethylenediamine tetracetic acid);
(b) 1.0% R-lipoic acid,
1.0% acetyl-1-carnitine,
1.0% carnosine,
0.2% Benfotiamine,
1.0% bilberry anthocyanin,
0.5% rosmarinic acid,
1.0% shark derived glycosaminoglycan, and
0.5% tocopherol;
(c) 1.0% R-dihydrolipoic acid,
2.0% acetyl-1-carnitine,
1.0% carnosine,
0.5% lutein,
3.0% tetrahexyldecylascorbate,
0.5% lycopene,
0.1% coenzyme Q10 (ubiquinone), and
0.5% curcumine;
(d) 1.0% R-lipoic acid,
1.0% R-dihydrolipoic acid,
1.0% acetyl-1-carnitine,
3.0% carnosine, and
1.0% NADH;
(e) 1.0% R-dihydrolipoic acid,
1.0% acetyl-1-carnitine,
3.0% carnosine,
1.0% dipalmitoyl-hydroxy-proline, and
1.0% wolfberry extract;
(f) 2.0% R-lipoic acid,
2.0% 1-carnitine,
2.0% 1-carnosine,
1.0% 1-glutathione,
2.0% bilberry anthocyanin,
1.0% rosemary extract, and
1.0% myristicin;
or
(g) 1.0% R-lipoic acid,
2.0% 1-carnitine,
2.0% 1-carnosine,
0.5% Huperzine-A, and
1.0% polyenylphosphatidylcholine;
and a dermatologically acceptable carrier;
wherein amounts are in weight percent and said composition is effective in the treatment of skin.
2. The method of claim 1 , wherein the composition comprises:
5.0% R-lipoic acid,
2.0% acetyl-1-carnitine,
1.0% carnosine,
1.0% astaxanthin,
0.5% tocotrienol,
0.5% tocopherol,
1.0% sesame oil,
0.5% grape proanthocyanidin, and
0.05% E.D.T.A. (ethylenediamine tetracetic acid);
and a dermatologically acceptable carrier.
3. The method of claim 1 , wherein the composition comprises:
1.0% R-lipoic acid,
1.0% acetyl-1-carnitine,
1.0% carnosine,
0.2% benfotiamine,
1.0% bilberry anthocyanin,
0.5% rosmarinic acid,
1.0% shark derived glycosaminoglycan, and
0.5% tocopherol;
and a dermatologically acceptable carrier.
4. The method of claim 1 , wherein the composition comprises:
1.0% R-dihydrolipoic acid,
2.0% acetyl-1-carnitine,
1.0% carnosine,
0.5% lutein,
3.0% tetrahexyldecylascorbate,
0.5% lycopene,
0.1% coenzyme Q10 (ubiquinone), and
0.5% curcumine;
and a dermatologically acceptable carrier.
5. The method of claim 1 , wherein the composition comprises:
1.0% R-lipoic acid,
1.0% R-dihydrolipoic acid,
1.0% acetyl-1-carnitine,
3.0% carnosine, and
1.0% NADH;
and a dermatologically acceptable carrier.
6. The method of claim 1 , wherein the composition comprises:
1.0% R-dihydrolipoic acid,
1.0% acetyl-1-carnitine,
3.0% carnosine,
1.0% dipalmitoyl-hydroxy-proline, and
1.0% wolfberry extract;
and a dermatologically acceptable carrier.
7. The method of claim 1 , wherein the composition comprises:
2.0% R-lipoic acid,
2.0% 1-carnitine,
2.0% 1-carnosine,
1.0% 1-glutathione,
2.0% bilberry anthocyanin,
1.0% rosemary extract, and
1.0% myristicin;
and a dermatologically acceptable carrier.
8. The method of claim 1 , wherein the composition comprises:
1.0% R-lipoic acid,
2.0% 1-carnitine,
2.0% 1-carnosine,
0.5% Huperzine-A, and
1.0% polyenylphosphatidylcholine;
and a dermatologically acceptable carrier.
9. The method of claim 1 , wherein the carnosine is L-carnosine.
10. The method of claim 1 , wherein the topical composition further comprises nicotinamide-adenine-dinucleotide.
11. The method of claim 1 , wherein the topical composition further comprises an antioxidant.
12. The method of claim 1 , wherein the topical composition further comprises an AGE inhibitor.
13. The method of claim 1 , wherein the topical composition further comprises a mitochondrial resuscitant.
14. The method of claim 13 , wherein the mitochondrial resuscitant is NTBHA, Mn-SOD, COQ10, creatine, D-ribose, pyruvate or stabilized ATP.
15. The method of claim 14 wherein the mitochondrial resuscitant is NTBHA.
16. The method of claim 1 , wherein the topical composition further comprises a collagen enhancing agent, a sunscreen agent, an anti-edemic agent, a glutathione or an inducers thereof, a collagenase-inhibitor, an anti-inflammatory agent, a phenylpropanoid glycoside, a depigmenting agent or agent addressing hyperpigmentation, a skin-protective lipids, hyaluronic acid, an alpha hydroxy acid, an agent useful for treating hormonal decline, an anti-acne agent, an agent altering lipolytic activity, an anti-cellulitic agent, an agent altering anti-capillary-fragility, an anti-elastase agent, an anti-erythema agent, or an agent that raises cyclic AMP.
17. The method of claim 1 , wherein the composition is encapsulated.
18. The method of claim 17 , wherein the composition is encapsulated in a liposome.
19. The method of claim 1 , wherein the composition is administered in a makeup.
20. The method of claim 19 , wherein the makeup is a foundation, a cover cream, or an eyeshadow.
21. The method of claim 1 , further comprising applying electricity to the skin.
22. The method of claim 21 , wherein the electricity is applied using an electronic patch or a portanble electronic device.
23. The method of claim 1 , further comprising applying light to the skin.
24. The method of claim 21 , further comprising applying light to the skin.