Methods of enhancing T cell responsiveness
View Patent ↗The invention features methods of enhancing the responsiveness of a T cell. Such methods involve interfering with the interaction between a T cell and a B7-H1 molecule.
1. A method of inhibiting tumor cell proliferation in a subject, comprising:
(a) identifying a subject with cancer; and
(b) administering to the subject an antibody that binds to B7-H1.
2. The method according to claim 1 , wherein cells of the cancer are identified as expressing B7-H1 molecules on their surfaces.
3. The method according to claim 1 , wherein said B7-H1 comprises the amino acid sequence set forth in SEQ ID NO: 3.
4. The method according to claim 1 , wherein said antibody interferes with an interaction between the T cell and B7-H1.
5. The method according to claim 1 , wherein said subject is a human.
6. The method according to claim 1 , wherein said subject is a mouse.
7. The method of claim 1 , wherein the cancer is a hematological cancer, a neurological cancer, breast cancer, a gastrointestinal cancer, or a genitourinary cancer.
8. The method of claim 7 , wherein the gastrointestinal cancer is colon cancer.
9. The method of claim 7 , wherein the genitourinary cancer is ovarian cancer.
10. The method of claim 1 , wherein the cancer is melanoma.
11. The method of claim 1 , wherein the cancer is lung cancer.
12. The method of claim 1 , wherein the cancer is head and neck cancer, liver cancer, pancreatic cancer, bone cancer, or a vascular cancer.
13. The method of claim 1 , wherein the antibody is a monoclonal antibody.
14. The method of claim 1 , wherein the antibody is a polyclonal antibody.
15. The method of claim 1 , wherein the antibody is an antigen-binding fragment.
16. The method of claim 15 , wherein the antigen-binding fragment is a single chain Fv fragment.
17. The method of claim 1 , wherein the antibody is a chimeric antibody.
18. The method of claim 1 , further comprising delivering one or more cytokines to the subject.
19. The method of claim 1 , further comprising administering an immunogenic stimulus to the subject.
20. The method of claim 19 , wherein the immunogenic stimulus comprises a tumor-associated antigen.