Methods and compositions for immunization against chlamydial infection and disease
View Patent ↗The present invention provides Chlamydia proteins and compositions and methods of use in the treatment/prevention of chlamydial infection in a subject, for eliciting an immune response in a subject and for reducing the likelihood of infertility and reducing the incidence and/or degree of hydrosalpinx due to Chlamydia infection in a subject.
1. A method of reducing the likelihood of infertility due to Chlamydia infection in a subject, comprising administering to the subject a composition comprising an effective amount of a chlamydial protease-like activity factor (CPAF) protein or an immunogenic fragment thereof, thereby treating Chlamydia infection, which thereby reduces the likelihood of infertility caused by said Chlamydia infection.
2. A method of reducing the likelihood of infertility due to Chlamydia infection in a subject, comprising administering to the subject a composition comprising:
a) an effective amount of a chlamydial protease-like activity factor (CPAF) protein or an immunogenic fragment thereof, and
b) an effective amount of a different chlamydial protein or immunogenic fragment thereof, thereby treating Chlamydia infection, which thereby reduces the likelihood of infertility caused by said Chlamydia infection.
3. The method of claim 1 , further comprising administering an adjuvant to the subject.
4. The method of claim 2 , further comprising administering an adjuvant to the subject.
5. The method of claim 3 , wherein the adjuvant is selected from the group consisting of: IL-12, CpG oligodeoxynucleotides, alum, Montanide ISA 720 and any combination thereof.
6. The method of claim 4 , wherein the adjuvant is selected from the group consisting of: IL-12, CpG oligodeoxynucleotides, alum, Montanide ISA 720 and any combination thereof.