Opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
1. A compound selected from the group:
6-[4-(Benzylamino-methyl)-phenylsulfanyl]-nicotinamide,
6-{4-[(3-Methyl-butylamino)-methyl]-phenylsulfanyl}-nicotinamide,
6-{4-[(2-Pyridin-4-yl-ethylamino)-methyl]-phenylsulfanyl}-nicotinamide,
6-[4-(Phenethylamino-methyl)-phenylsulfanyl]-nicotinamide,
6-{4-[(Cyclopropylmethyl-amino)-methyl]-phenylsulfanyl}-nicotinamide,
6-{4-[(2-Thiophen-2-yl-ethylamino)-methyl]-phenylsulfanyl}-nicotinamide,
6-{4-[(3-Phenyl-propylamino)-methyl]-phenylsulfanyl}-nicotinamide,
6-{4-[(3-Methyl-butylamino)-methyl]-phenylsulfanyl}-nicotinamide,
4-[4-(Phenethylamino-methyl)-benzenesulfonyl]-benzamide,
4-[4-(Phenethylamino-methyl)-benzenesulfinyl]-benzamide,
6-{4-[(2-Pyridin-4-yl-ethylamino)-methyl]-phenylsulfanyl}-nicotinamide,
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound according to claim 1 in association with a carrier, diluent and/or excipient.