Substituted pyridoxazines

1. A compound of the structure of formula I

or a stereoisomer, racemate or salt thereof, wherein:

A is selected from the group consisting of (CH 2 ) n , CO(CH 2 ) n , and SO 2 (CH 2 ) n ;

Y is selected from the group consisting of CH 2 and CO;

R 1 is selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, —NR 5 R 6 , aryl, and 4- to 10-membered heterocyclyl, wherein the aryl of R 1 is optionally substituted with 1 to 5 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, O-aryl, CN, NO 2 , OCF 3 , and CF 3 ; and the 5- to 10-membered heterocyclyl of R 1 is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, CN, NO 2 , OCF 3 , and CF 3 ;

R 2 and R 3 are each independently selected from the group consisting of H and C 1 -C 3 alkyl;

R 4 is CONR 7 R 8 , or

wherein W is selected from the group consisting of N, NR 17 , O, CR 9 R 10 , CR 9 R 10 CR 11 R 12 , and CR 13 ; X is selected from the group consisting of N, NR 17 , CO, CR 14 , and CR 15 R 16 ; and Z is selected from the group consisting of NR 17 , O, and S;

R 5 and R 6 are independently selected from the group consisting of hydrogen, C 1 -C 6 alkyl, (CH 2 ) n C 3 -C 8 cycloalkyl, (CH 2 ) n aryl, (CH 2 ) n -5- to 10-membered heterocyclyl, wherein the aryl of (CH 2 ) n aryl and heterocycle of (CH 2 ) n -5- to 10-membered heterocyclyl of R 5 and R 6 are each optionally substituted with 1 to 5 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, CN, OCF 3 , and CF 3 ; alternatively, R 5 and R 6 , taken together with nitrogen atom to which they are bonded, form a 4- to 10-membered heterocyclyl optionally substituted with 1 to 4 substituents independently selected from the group consisting of halogen, C 1 -C 3 alkyl, CF 3 , aryl, 5- to 6-membered heterocyclyl, and NR 28 R 29 ;

R 7 and R 8 are independently selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n C 3 -C 8 cycloalkyl, (CH 2 ) n aryl, (CH 2 ) n -4- to 10-membered heterocyclyl, and (CH 2 ) q CR 18 R 19 R 20 , wherein the (CH 2 ) n aryl, (CH 2 ) n -linked 4- to 10-membered heterocyclyl of R 7 and R 8 are each optionally substituted with 1 to 4 substituents independently selected from the group consisting of halogen, CN, NO 2 , CF 3 , OCF 3 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; alternatively, R 7 and R 8 , taken together with nitrogen atom to which they are bonded, form a 4- to 10-membered heterocyclyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, CF 3 , OCF 3 , C 1 -C 6 alkyl, C 1 -C 6 alkyl-OR 24 , COR 24 , OR 24 , (CH 2 ) n COOR 24 , CONR 24 R 25 , (CH 2 ) n NR 24 R 25 , SO 2 R 24 , SO 2 NR 24 R 25 , and 5- to 6-membered heterocyclyl;

each instance of R 9 , R 10 , R 11 , and R 12 is independently selected from the group consisting of H and C 1 -C 6 alkyl;

R 13 is selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n —C 3 -C 8 cycloalkyl, and aryl;

R 14 is selected from the group consisting of H, C 1 -C 6 alkyl, CONR 26 R 27 , and aryl, wherein the aryl of R 14 is optionally substituted with 1 to 4 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, CN, OCF 3 , and CF 3 ;

alternatively, R 13 and R 14 , taken together with atoms to which they are bonded, form a 5- to 6-membered saturated, partially unsaturated, or unsaturated cycloalkyl, or a 5- to 7-membered heterocyclyl, each of which are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen and C 1 -C 3 alkyl;

each instance of R 15 , R 16 , and R 17 is independently selected from the group consisting of H and C 1 -C 6 alkyl

R 18 is selected from the group consisting of H, C 1 -C 6 alkyl, CN, COR 21 , (CH 2 ) m OR 22 , (CH 2 ) m NR 22 R 23 , (CH 2 ) n COOR 22 , and (CH 2 ) n CONR 22 R 23 ;

R 19 is selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n C 3 -C 8 cycloalkyl, and (CH 2 ) m OR 22 ;

R 20 is selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n C 3 -C 8 cycloalkyl, and aryl;

R 21 is selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n C 3 -C 8 cycloalkyl, and aryl;

alternatively,

(i) R 19 and R 20 , taken together with the atom to which they are bonded, form a 3- to 6-membered cycloalkyl or 4- to 7-membered heterocyclyl; wherein the 3- to 6-membered cycloalkyl or 4- to 7-membered heterocyclyl are each optionally substituted with 1 to 2 substituents independently selected from the group consisting of halogen, C 1 -C 3 alkyl, and OR 22 ; or

(ii) R 20 and R 21 , taken together with atoms to which they are bonded, form a 5- to 7-membered cycloalkyl or 5- to 7-membered heterocyclyl;

R 22 is selected from the group consisting of H, C 1 -C 6 alkyl, and (CH 2 ) n C 3 -C 8 cycloalkyl;

R 23 is selected from the group consisting of H, C 1 -C 6 alkyl, and (CO)C 1 -C 6 alkyl;

alternatively, R 22 and R 23 , taken together with the nitrogen atom to which they are bonded, form a 4- to 10-membered heterocyclyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, CF 3 , OCF 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, and SO 2 —C 1 -C 6 alkyl;

R 24 is selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n C 3 -C 8 cycloalkyl, aryl, and 4- to 10-membered heterocyclyl, wherein the aryl and 4- to 10-membered heterocyclyl are each optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, CF 3 , OCF 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy;

R 25 is selected from the group consisting of H, C 1 -C 6 alkyl, and CO—C 1 -C 6 alkyl;

alternatively, R 24 and R 25 , taken together with the nitrogen atom to which they are bonded, form a 4- to 10-membered heterocyclyl;

R 26 and R 27 are independently selected from the group consisting of H, C 1 -C 6 alkyl, (CH 2 ) n —C 5 -C 8 cycloalkyl, and C 2 -C 8 alkyloxyalkyl, or R 26 and R 27 , taken together with nitrogen atom to which they are bonded, form a 5- to 9-membered heterocyclyl;

each instance of R 28 and R 29 is independently selected from the group consisting of H and C 1 -C 6 alkyl; alternatively, R 28 and R 29 , taken together with the nitrogen to which they are bonded, form a 4-6 membered heterocyclyl optionally substituted with 1 to 4 substituents independently selected from the group consisting of halogen and C 1 -C 6 alkyl;

each instance of n, m and q is independently selected from 0 and an integer from 1 to 3;

provided that m and q are not both zero; and

provided that if A is SO 2 , R 1 is aryl or substituted aryl, and R 7 is H, then R 8 is not aryl, heteroaryl, substituted aryl, or substituted heteroaryl.

2. The compound according to claim 1 , wherein A is SO 2 .

3. The compound according to claim 1 , wherein A is CH 2 .

4. The compound according to claim 1 , wherein:

R 1 is aryl, optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, and CF 3 ; and

R 2 and R 3 are both H.

5. The compound according to claim 1 , wherein R 1 is NR 5 R 6 .

6. The compound according to claim 5 , wherein R 5 and R 6 are each independently selected from the group consisting of C 1 -C 6 alkyl, (CH 2 ) n aryl, 5- to 10-membered heterocyclyl, wherein the aryl of (CH 2 ) n aryl and the 5- to 10-membered heterocyclyl of R 5 and R 6 are each optionally substituted with 1 to 5 substituents independently selected from the group consisting of halogen, C 1 -C 6 alkyl, CN, OCF 3 , and CF 3 .

7. The compound according to claim 1 , wherein R 5 and R 6 , taken together with nitrogen atom to which they are bonded, form a 4- to 10-membered heterocyclyl optionally substituted with 1 to 4 substituents independently selected from the group consisting of halogen, C 1 -C 3 alkyl, CF 3 , aryl, 5- to 6-membered heterocyclyl, and NR 28 R 29 .

8. The compound according to claim 1 , wherein R 2 and R 3 are both H; R 4 is CONR 7 R 8 , and R 7 is selected from the group consisting of H and C 1 -C 6 alkyl.

9. The compound according to claim 1 , wherein R 2 and R 3 are both H; and R 4 is

wherein X is selected from the group consisting of N, CR 14 , and CR 15 R 16 ; and Z is selected from the group consisting of NR 17 and O.

10. The compound according to claim 9 , wherein R 13 and R 14 , taken together with atoms to which they are bonded, form a 5- to 6-membered partially unsaturated, or unsaturated cycloalkyl, or a 5- to 7-membered heterocyclyl, each of which are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen and C 1 -C 3 alkyl.

11. The compound according to claim 9 , wherein W is O and Z is NH.

12. The compound according to claim 9 , wherein X is CR 14 , and Z is N.

13. The compound according to claim 1 , wherein

A is SO 2 ;

R 1 is aryl optionally substituted with 1 to 5 substituents independently chosen from halogen, C 1 -C 6 alkyl, CN, OCF 3 , and CF 3 ;

R 2 and R 3 are each independently selected from the group consisting of H and CH 3 ;

R 4 is CONHR 8 ; wherein R 8 is selected from the group consisting of C 1 -C 6 alkyl, and (CH 2 ) q CR 18 R 19 R 20 ; wherein R 18 is selected from the group consisting of (CH 2 ) m OR 22 , (CH 2 ) n COOR 22 , and (CH 2 ) n CONR 22 R 23 ; and R 19 and R 20 are each independently C 1 -C 6 alkyl.

14. The compound according to claim 1 , wherein

A is SO 2 ;

R 1 is NR 5 R 6 ;

R 2 and R 3 are each independently selected from the group consisting of H and CH 3 ;

R 4 is CONHR 8 ; wherein R 8 is selected from the group consisting of C 1 -C 6 alkyl and (CH 2 ) q CR 18 CR 19 CR 20 ; wherein R 18 is (CH 2 ) m OR 22 , (CH 2 ) n COOR 22 , and (CH 2 ) n CONR 22 R 23 ; and R 19 and R 20 are each independently C 1 -C 6 alkyl.

15. The compound according to claim 1 , wherein

A is SO 2 ;

R 1 is selected from the group consisting of C 1 -C 6 alkyl, aryl, haloaryl, and CF 3 aryl;

R 2 and R 3 are each independently selected from the group consisting of H and CH 3 ; and

R 4 is

wherein X is selected from the group consisting of N, CR 14 , and CR 15 R 16 ; and Z is selected from the group consisting of NR 17 and O.

16. The compound according to claim 1 , wherein

A is selected from the group consisting of CH 2 and SO 2 ;

R 1 is NR 5 R 6 ;

R 2 and R 3 are each independently selected from the group consisting of H and CH 3 ; and

R 4 is

wherein X is selected from the group consisting of N, CR 14 , and CR 15 R 16 ; and Z is selected from the group consisting of NR 17 and O.

17. The compound according to claim 1 , selected from the group consisting of

(1-(phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(piperidin-1-yl)methanone;

N-tert-butyl-1-(piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b]-[1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-cyanophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

morpholino(1-(phenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

N-tert-butyl-1-(phenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(S)—N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-1-(phenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-fluoro-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluorophenyl-sulfonyl)-N-isobutyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluorophenyl-sulfonyl)-N-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluorophenyl-sulfonyl)-N-neopentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluorophenyl-sulfonyl)-N-(3-methoxypropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(4-fluorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N,N-diethyl-1-(4-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluorophenyl-sulfonyl)-N-((tetrahydrofuran-2-yl)methyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(S)—N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-1-(4-fluorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(pyridin-3-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(pyridin-3-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N,N-diethyl-1-(pyridin-3-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-methoxypropyl)-1-(pyridin-3-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(3-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(2-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(2-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-chlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chlorophenyl-sulfonyl)-N-cyclopentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(isobutylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(isobutylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(1-methyl-1H-imidazol-4-ylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(1-methyl-1H-imidazol-4-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-benzyl-1-(4-fluorophenylsulfonyl)-N-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chlorophenyl-sulfonyl)-N-(cyclopropyl-methyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chlorophenyl-sulfonyl)-N-(2-methoxy-ethyl)-N-methyl-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-(2-methoxyethyl)-N-methyl-1-(4-(trifluoro-methyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-benzyl-N-methyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-(2-methyl-1-(pyrrolidin-1-yl)propan-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(2-(dimethylamino)-ethyl)-N-ethyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methyl-propan-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-N-methyl-1-(4-(trifluoromethyl)-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-N-(2-cyanoethyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-N-ethyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-N-(2-methoxyethyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-N-(2-hydroxyethyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-aminopropyl)-N-tert-butyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(2-methyl-1-morpholinopropan-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(2-amino-2-methylpropyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-(trifluoromethoxy)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

piperidin-1-yl(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

morpholino(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

N-(2-methoxyethyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

1′,1′-dioxide-thiomorpholino(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

N-tert-butyl-1-(3,5-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(2,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-fluoro-2-methylphenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(2-chloro-4-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(S)—N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-1-(4-fluorophenylsulfonyl)-N-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(5-methylthiophen-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(benzylsulfonyl)-N-tert-butyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-chlorobenzylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-fluorobenzylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-(trifluoromethyl)benzylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-(hydroxymethyl)butan-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-(trifluoromethyl)-phenylsulfonyl)-N-(2,4,4-trimethylpentan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-pentyl-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b]-[1,4]oxazine-7-carboxamide;

N-(1-(hydroxymethyl)-cyclopentyl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(S)-methyl 1-(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carbonyl)piperidine-2-carboxylate;

(S)-(2-methylpiperidin-1-yl)(1-(4-(trifluoromethyl)-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-methanone;

ethyl 1-(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamido)-cyclopropanecarboxylate;

ethyl 1-(1-(4-(trifluoro-methyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamido)cyclo-butanecarboxylate;

+/−(2-(hydroxymethyl)piperidin-1-yl)(1-(4-(trifluoro-methyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

+/−methyl 2-(1-(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carbonyl)piperidin-2-yl)acetate;

+/−(2-(methoxymethyl)-piperidin-1-yl)(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

+/−(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)(1-(4-(trifluoromethyl)-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-methanone;

+/−(2-(morpholino-methyl)piperidin-1-yl)(1-(4-(trifluoromethyl)-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

N-(2-methyl-1-(piperidin-1-yl)propan-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(R)-1-(1-(4-(trifluoro-methyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carbonyl)piperidine-2-carboxylic acid;

N-tert-butyl-1-(propylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(ethylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3-methylbenzylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-tert-butylphenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(2-(trifluoromethoxy)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3-(trifluoromethoxy)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(m-tolylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(naphthalen-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(naphthalen-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3-chlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(thiophen-3-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(2,5-dimethylthiophen-3-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-methylthiophen-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-phenoxyphenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(5-chlorothiophen-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloro-2-fluorophenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloro-2-fluorophenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3-chloro-4-fluorophenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3-chloro-4-methoxyphenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3-fluoro-4-methoxyphenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(2,4-difluorophenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(2-fluoro-4-methoxyphenylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3-chloro-4-methoxyphenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3-fluoro-4-methoxyphenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(2,4-difluorophenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(2-fluoro-4-methoxyphenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3-chloro-4-fluorophenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-difluorophenylsulfonyl)-N-(2-hydroxy-2-methylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenylsulfonyl)-N-((1S,2S)-2-hydroxycyclopentyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloro-2-fluorophenylsulfonyl)-N-((1S,2S)-2-hydroxycyclopentyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenylsulfonyl)-N-(2-methyl-1-morpholinopropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloro-2-fluorophenylsulfonyl)-N-(2-methyl-1-morpholinopropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenyl-sulfonyl)-N-(2-hydroxyethyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloro-2-fluorophenylsulfonyl)-N-(2-hydroxyethyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(1-(3,4-dichloro-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(4-(methylsulfonyl)piperazin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(4-(pyridin-2-ylsulfonyl)piperazin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(4-(phenylsulfonyl)piperazin-1-yl)methanone;

4-(1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carbonyl)-N,N-dimethyl piperazine-1-sulfonamide;

1-(3,4-dichlorophenyl-sulfonyl)-N-(2-hydroxy-ethyl)-N-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenyl sulfonyl)-N-(3-hydroxy-2,2-dimethylpropyl)-N-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(R)-(1-(3,4-dichlorophenyl sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(2-(hydroxymethyl)pyrrolidin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(4-methylpiperazin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(4,4-dimethyl-oxazolidin-3-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(3-hydroxyazetidin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(3,3-difluoro-pyrrolidin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(4-hydroxypiperidin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(3,3-difluoroazetidin-1-yl)methanone;

(1-(3,4-dichlorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)(3-methoxyazetidin-1-yl)methanone;

azetidin-1-yl(1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

1-(3,4-dichlorophenyl-sulfonyl)-N-(3-hydroxy-2,2-dimethylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenyl-sulfonyl)-N-((1S,2R)-2-hydroxycyclopentyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenyl-sulfonyl)-N-((1R,2R)-2-hydroxycyclopentyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenyl-sulfonyl)-N-(trans-4-hydroxycyclohexyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dichlorophenyl-sulfonyl)-N-((1R,2R)-2-hydroxycyclohexyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

methyl 2-(1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamido)-2-methylpropanoate;

N-cyclobutyl-1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-benzyl-1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

ethyl 1-(1-(3,4-dichloro-phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamido)cyclobutanecarboxylate;

N-tert-butyl-1-(morpholinosulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-1-(morpholinosulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

1-(morpholinosulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide

1-(N,N-dimethyl-sulfamoyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(N,N-dimethyl-sulfamoyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(N,N-dimethylsulfamoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-1-(piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(2-methyl-1-morpholinopropan-2-yl)-1-(piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(pyrrolidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-1-(pyrrolidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-pentyl-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-tert-butylisoxazol-5-yl)-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(5-tert-butylisoxazol-3-yl)-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4,4-difluoropiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4,4-difluoropiperidin-1-ylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-phenylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-pentyl-1-(4-phenylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-1-(4-phenylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-1-(4-phenylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(5-tert-butylisoxazol-3-yl)-1-(4-phenylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3,3-difluoropyrrolidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,3-difluoropyrrolidin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(5-tert-butylisoxazol-3-yl)-1-(3,3-difluoro-pyrrolidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-fluoropiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluoropiperidin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluoropiperidin-1-ylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluoropiperidin-1-ylsulfonyl)-N-(3-hydroxy-2,2-dimethylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-methylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-methylpiperidin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-1-(4-methylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-1-(4-methylpiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-methylpiperazin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-methylpiperazin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-(pyrrolidin-1-yl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-pentyl-1-(4-(pyrrolidin-1-yl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

1-(N-benzylsulfamoyl)-N-tert-butyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(N-benzylsulfamoyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(N-isobutylsulfamoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(1-hydroxy-2-methylpropan-2-yl)-1-(N-isobutylsulfamoyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-(3-hydroxy-2,2-dimethylpropyl)-1-(N-isobutylsulfamoyl)-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(isoindolin-2-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4-chloropiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloropiperidin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloropiperidin-1-ylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chloropiperidin-1-ylsulfonyl)-N-(3-hydroxy-2,2-dimethylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido-[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-(3-hydroxy-2,2-dimethylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)-N-(3-hydroxy-2,2-dimethyl-propyl)-N-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(3,3-difluoroazetidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,3-difluoroazetidin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,3-difluoroazetidin-1-ylsulfonyl)-N-(1-hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(3,3-difluoroazetidin-1-ylsulfonyl)-N-(3-hydroxy-2,2-dimethylpropyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

(cis-2,6-dimethylpiperidin-1-yl)(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

(2,6-dimethylmorpholino)(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

(2,6-dimethylmorpholino)(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

(3,5-dimethylpiperidin-1-yl)(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

(3,5-dimethylpiperidin-1-yl)(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)methanone;

methyl 4-(1-(3,4-dichlorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamido)tetrahydro-2H-pyran-4-carboxylate;

1-(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamido)cyclopropanecarboxylic acid;

2-(1-(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carbonyl)piperidin-2-yl)acetic acid;

1-(1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamido)cyclobutanecarboxylic acid;

1-(3,4-dichlorophenylsulfonyl)-N-(1-(hydroxymethyl)cyclobutyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

7-(3-ethyl-1,2,4-oxadiazol-5-yl)-1-(phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

7-(5-phenyl-1,3,4-oxadiazol-2-yl)-1-(phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

7-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(4-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

N-cyclopentyl-5-(1-(4-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-1,2,4-oxadiazole-3-carboxamide;

N-tert-butyl-5-(1-(4-fluoro-phenyl sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-1,2,4-oxadiazole-3-carboxamide;

(5-(1-(4-fluorophenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-1,2,4-oxadiazol-3-yl)(morpholino)methanone;

5-(1-(4-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-3-carboxamide;

7-(oxazolo[4,5-b]pyridin-2-yl)-1-(phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

N-tert-butyl-1-(4-fluorobenzyl)-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-benzyl-N-cyclopentyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-benzyl-N-tert-butyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-cyclopentyl-1-(4-fluorobenzyl)-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-chlorobenzyl)-N-cyclopentyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

7-(5,5-dimethyl-2,5-dihydro-1,2,4-oxadiazol-3-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

7-(4,4-dimethyl-4,5-dihydro-1H-imidazol-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

7-(5,5-dimethyl-1,4,5,6-tetrahydropyrimidin-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine;

7-(5-phenyl-1H-imidazol-2-yl)-1-(4-(trifluoromethyl)phenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine; and

7-(5-phenyloxazol-2-yl)-1-(4-(trifluoromethyl)phenyl-sulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine.

18. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable diluent, excipient, or carrier.

19. The compound according to claim 1 , selected from the group consisting of

N-tert-pentyl-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

N-tert-butyl-1-(4,4-difluoropiperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

1-(4-fluoropiperidin-1-ylsulfonyl)-N-tert-pentyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide;

7-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-1-(4-fluorophenylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine; and

N-tert-butyl-1-(4-fluorobenzyl)-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide.

20. The compound according to claim 1 , having the structure defined by N-(3-tert-butylisoxazol-5-yl)-1-(4-(trifluoromethyl)piperidin-1-ylsulfonyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carboxamide.