Electromagnetic treatment of tissues and cells
Provided herein are methods, devices and compositions to conductively or to inductively fix substrates, including tissues, using electromagnetic energy. Also provided is a method of controlling the fixing process via feedback monitoring of a property of the composition and/or of the electromagnetic energy used.
1. A method of treatment for one or more substrates in an individual, comprising:
securing said substrate(s) proximal to a susceptor, wherein said substrate is intact and said susceptor is a dissociable ion, or a mixture of dissociable ions;
applying radiofrequency energy that generates a magnetic field to said substrate(s) or to said susceptor or to a combination thereof to inductively generate heat therein;
affixing said substrate(s) via said heat thereby effecting treatment; and
controlling the affixing of said substrate(s) via feedback monitoring of a property of said susceptor, said energy or a combination thereof.
2. The method of claim 1 , wherein said substrate(s) is a tissue, an implant or a bandage.
3. The method of claim 1 , wherein said substrate is secured by a surgical fastener, a laminate or a surgical fitting further comprised of a fusion composition.
4. The method of claim 3 , wherein said surgical fastener is a staple, a clip or a suture.
5. The method of claim 1 , wherein said substrate is secured by an adherend.
6. The method of claim 5 , wherein said adherend is a protein or a polymer.
7. The method of claim 1 , wherein said energy is applied in pulses.
8. The method of claim 1 , wherein said radiofrequency energy has a frequency of about 20 kHz to about 40 GHz.
9. The method of claim 1 , wherein said magnetic field is generated via a substantially flat antenna.
10. The method of claim 9 , wherein said antenna comprises at least one coil of electrical conductor.
11. The method of claim 10 , wherein said electrical conductor is a solid wire or hollow tubing.
12. The method of claim 9 , wherein said antenna is a single coil antenna, or a double coil antenna.
13. The method of claim 1 , wherein affixing said substrate(s) forms a scaffold or a lattice structure within said substrate or between substrates.
14. The method of claim 1 , wherein affixing said substrate(s) seals a tissue, fills a tissue defect, or bonds tissues together.
15. The method of claim 1 , wherein said property is heat, an electrical property, eddy currents, conductivity, or frequency changes or a combination thereof.
16. The method of claim 15 , wherein heat is monitored via optical detection.
17. The method of claim 16 , wherein said optical detection is infrared.