Use of neurotoxin therapy for treatment of urologic and related disorders
The present invention related to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin.
1. A method of increasing in bladder capacity in a patient with a voiding dysfunction comprising administering a therapeutically effective amount of botulinum toxin Type A to the bladder of the patient, whereby bladder capacity is increased.
2. The method of claim 1 , wherein the botulinum toxin is administered in a pharmaceutically acceptable formulation.
3. The method of claim 1 , wherein the administration comprises an injection of botulinum toxin type A.
4. The method of claim 1 , wherein the therapeutically effective amount is 200 IU of botulinum toxin type A.
5. The method of claim 1 , wherein the administration is serial administration.
6. The method of claim 1 , wherein the therapeutically effective amount is 800 IU of botulinum toxin type A administered serially.
7. The method of claim 1 , wherein the therapeutically effective amount is about 1.4 IU/kg to 17.1 IU/kg of botulinum toxin type A.
8. The method of claim 1 , wherein the therapeutically effective amount is about 2500 IU of botulinum toxin type.
9. The method of claim 1 , wherein the administration is to the bladder wall of the bladder.
10. The method of claim 1 , wherein the administration is to the lateral bladder wall of the bladder.
11. The method of claim 1 , wherein bladder capacity increases from about 150 cc before administration to about 300-400 cc after administration.
12. A method of increasing in bladder capacity in a patient comprising administering botulinum toxin Type A to the lateral bladder wall of the patient, whereby bladder capacity is increased.
13. The method of claim 12 , wherein bladder capacity increases from about 150 cc before administration to about 300-400 cc after administration.
14. The method of claim 12 , wherein administration is up to about 2500 units.
15. The method of claim 12 , wherein administration comprises injection.
16. The method of claim 12 , wherein the administration comprises delivery by a liquid, emulsions, or suspensions.