Compounds that bind to p185 and methods of using the same
View Patent ↗Novel peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic agents are disclosed. Method of detecting tumors that have p185 on tumor cell surfaces are disclosed. Methods of preventing transformation of a normal cell into a tumor cell in an individual at risk of developing a tumor having tumor cells which have p185 on their surfaces are disclosed. Methods of treating an individual who has cancer characterized by tumor cells that have a p185 on their cell surfaces are disclosed.
1. A method of treating an individual who has cancer characterized by p185-expressing tumor cells, comprising administering to said individual a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an isolated cyclic peptide having an amino acid sequence:
YCDGFYACYMDV-NH 2 (SEQ ID NO:113 wherein the carboxy terminus is amidated);
FCDGFYACYMDVK-NH 2 (SEQ ID NO:123 wherein the carboxy terminus is amidated); or
GFCDGFYACYMDV-OH (SEQ ID NO:134 wherein the carboxy terminus is hydroxylated).
2. A method of treating an individual who has cancer characterized by p185-expressing tumor cells, comprising administering to said individual a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a detectable agent and/or a cytotoxic agent conjugated to an isolated cyclic peptide having an amino acid sequence:
YCDGFYACYMDV-NH 2 (SEQ ID NO:113 wherein the carboxy terminus is amidated);
FCDGFYACYMDVK-NH 2 (SEQ ID NO:123 wherein the carboxy terminus is amidated); or
GFCDGFYACYMDV-OH (SEQ ID NO:134 wherein the carboxy terminus is hydroxylated).
3. The method of claim 2 , wherein the peptide is administered in combination with a cytotoxic agent.
4. The method of claim 3 , wherein the cytotoxic agent is tamoxifen.
5. The method of claim 3 , wherein the cytotoxic agent is a radioisotope.
6. The method of claim 5 , wherein the radioisotope is 99M Tc, 90 Y or 18 F.