Methods of inhibiting tumor growth using blocking antibodies to IL-23R
View Patent ↗Provided are methods of treatment for tumors. In particular, methods are provided for modulating activity of a cytokine molecule and its receptor.
1. A method of treating a subject suffering from a cancer or tumor comprising administering to the subject an effective amount of a binding composition comprising an antigen-binding site of a blocking antibody that specifically binds to a polypeptide comprising residues 1-606 of SEQ ID NO: 6.
2. The method of claim 1 , wherein the binding composition inhibits:
a) growth of the cancer or tumor;
b) cachexia;
c) anorexia; or
d) angiogenesis.
3. The method of claim 1 , wherein the cancer or tumor is of the:
a) gastrointestinal tract;
b) respiratory tract;
c) reproductive system; or
d) endocrine system.
4. The method of claim 1 , wherein the cancer or tumor is:
a) colon cancer;
b) ovarian cancer;
c) a melanoma; or
d) breast cancer.
5. The method of claim 1 , wherein the binding composition comprises a polyclonal antibody.
6. The method of claim 1 , wherein the binding composition comprises a monoclonal antibody.
7. The method of claim 1 , wherein the binding composition comprises a humanized antibody, or a fragment thereof.
8. The method of claim 1 , wherein the binding composition comprises an Fab, Fv, or F(ab′) 2 fragment.
9. A method of treating a subject suffering from a cancer or tumor comprising administering to the subject an effective amount of a binding composition comprising an antigen-binding site of a blocking antibody that specifically binds to a polypeptide comprising the sequence of SEQ ID NO: 6.