Use of 3-methoxy-pregnenolone in the production of a medicament for treating neurodegenerative diseases
The invention relates to a novel use of derivatives of neurosteroids, particularly pregnenolone, for the treatment of acute or chronic lesions of the nervous system, especially certain neurodegenerative diseases, related in particular to the ability thereof to stabilize and/or increase the polymerization of neuronal microtubules.
1. A method for treating an acute or chronic spinal cord lesion in a patient comprising administering to the patient a composition comprising 3β-methoxy-pregna-5-ene-20-one (3β-methoxy-PREG),
wherein the composition is administered to the patient in an amount effective to treat the acute or chronic spinal cord lesion.
2. The method according to claim 1 , wherein said acute or chronic spinal cord lesion is spinal cord compression.
3. The method according to claim 1 , wherein said composition is administered by injection.
4. The method according to claim 1 , wherein said composition is administered orally.
5. The method according to claim 1 , wherein said composition comprises a quantity of 3β-methoxy-PREG ranging between 50 and 2500 mg.