IP Library Granted Patent US 8,040,135
Granted Patent B1
US 8,040,135 · App. 12/789,315 · Granted Oct 18, 2011

Contrast and resolution enhancement with signal compensation

Assignee: The Board of Trustees of the Leland Stanford Junior University
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Quick Facts
Patent No.
US 8,040,135
App. No.
12/789,315
Granted
Oct 18, 2011
Kind
B1
Abstract

A method for enhancing resolution and contrast in an MRI image is provided. A transient signal acquisition is applied to acquire a plurality of samples of data, comprising reducing transient signal oscillations and acquiring a plurality of MRI samples of data. Transient signal compensation is applied to the plurality of samples of data to provide data with signal compensation. A noise reduction technique is applied to the data with signal compensation. Data resulting from the applying the noise reduction is used to generate an MRI image.

Claims (46)

1. A method for enhancing resolution and contrast in an MRI image for execution on a magnetic resonance image (MRI) system comprising a magnet system and a controller for controlling the magnet system, comprising:

applying a transient signal acquisition by the controller through the magnet system to acquire a plurality of samples of data, comprising;

reducing transient signal oscillations; and

acquiring a plurality of MRI samples of data;

applying by the controller transient signal compensation to the plurality of samples of data to provide data with signal compensation;

applying by the controller a noise reduction technique to the data with signal compensation; and

using data resulting from the applying the noise reduction to generate through the controller an MRI image.

2. The method, as recited in claim 1 , wherein the applying a transient signal acquisition comprises applying a T 2 preparation.

3. The method, as recited in claim 2 , wherein the reducing transient signal oscillations comprises applying ramp catalyzation.

4. The method, as recited in claim 3 , wherein the acquiring a plurality of MRI samples of data comprises performing alternating repetition time (ATR) steady-state free procession (SSFP) acquisition to acquire a plurality of samples of data.

5. The method, as recited in claim 4 , wherein the applying the noise reduction technique to the data comprises applying compressed sensing to the data with signal compensation.

6. The method, as recited in claim 5 , wherein the applying compressed sensing to data comprises applying an iterative optimization algorithm to the data.

7. The method, as recited in claim 6 , wherein the applying transient signal compensation comprises applying decay compensation to the plurality of samples of data.

8. The method, as recited in claim 7 , wherein a transient signal decay curve proceeds from high-to-low and the decay compensation weights higher spatial frequencies more heavily than lower spatial frequencies.

9. The method, as recited in claim 7 , wherein a transient signal decay curve proceeds from low-to-high and the decay compensation weights higher spatial frequencies less heavily than lower spatial frequencies.

10. The method, as recited in claim 8 , wherein the decay compensation increases a contrast between a first species and a second species.

11. The method, as recited in claim 10 , wherein the MRI image is an angiographic image.

12. The method, as recited in claim 10 , wherein the performing the ATR SSFP acquisition comprises providing at least two consecutive repetition times of different durations and with phase cycling to create a stop-band to suppress a third background species.

13. The method, as recited in claim 12 , wherein the applying the T 2 preparation further comprises generating a BIR-4 pulse.

14. The method, as recited in claim 13 , wherein the iterative optimization algorithm solves the optimization problem

minimize∥m∥ 1 +λTV(m)

s.t.∥F u m−y∥ 2 <ε.

15. The method, as recited in claim 1 , wherein the reducing transient signal oscillations comprises applying ramp catalyzation.

16. The method, as recited in claim 1 , wherein the acquiring a plurality of MRI samples of data comprises performing alternating repetition time (ATR) steady-state free procession (SSFP) acquisition to acquire a plurality of samples of data.

17. The method, as recited in claim 1 , wherein the applying the noise reduction technique to the data comprises applying compressed sensing to the data with signal compensation.

18. A method for enhancing resolution and contrast in an MRI image for execution on a magnetic resonance imaging (MRI) system comprising a magnet system and a controller for controlling the magnet system, comprising:

applying a transient signal acquisition by the controller through the magnet system to acquire a plurality of samples of data, comprising;

applying T 2 preparation;

applying ramp catalyzation; and

performing alternating repetition time (ATR) steady-state free procession (SSFP) acquisition to acquire a plurality of samples of data;

applying by the controller decay compensation to the plurality of samples of data to provide data with signal compensation;

applying by the controller an iterative optimization algorithm to data with decay compensation; and

using data resulting from the iterative optimization algorithm to generate through the controller an MRI image.

19. An apparatus for providing magnetic resonance imaging, comprising:

a magnetic resonance imaging excitation and detection system; and

a controller electrically connected to the magnetic resonance imaging excitation and detection system, comprising:

a display;

at least one processor; and

non-transitory computer readable media, comprising:

computer readable code for applying a transient signal acquisition to acquire a plurality of samples of data; comprising

computer readable code for reducing transient signal oscillations; and

computer readable code for acquiring a plurality of MRI samples of data;

computer readable code for applying transient signal compensation to the plurality of samples of data to provide data with signal compensation;

computer readable code for applying a noise reduction technique to the data with signal compensation;

computer readable code using data resulting from the compressed sensing to generate an MRI image; and

computer readable code for displaying the MRI image.

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 17, 2010
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 025002/0524 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2010
From: CUKUR, TOLGA; LUSTIG, MICHAEL
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 024452/0912 →